23616-29-7

Basic information

• Product Name: 1,6-NAPHTHYRIDIN-2(1H)-ONE
• Synonyms: 1,6-NAPHTHYRIDIN-2(1H)-ONE;1,6-naphthyridin-2-ol;1H-1,6-naphthyridin-2-one;2-Hydroxy-1,6-naphthyridine
• CAS NO: 23616-29-7
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.15
• Mol File: 23616-29-7.mol
• Article Data: 8

Chemical Properties

• Melting Point: 303-304℃
• Boiling Point: 391.8 °C at 760 mmHg
• Flash Point: 190.8 °C
• Appearance: /
• Density: 1.267±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 2.4E-06mmHg at 25°C
• Refractive Index: 1.602
• Storage Temp.: 2-8°C
• PKA: 11.12±0.20(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1,6-NAPHTHYRIDIN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-NAPHTHYRIDIN-2(1H)-ONE(23616-29-7)
• EPA Substance Registry System: 1,6-NAPHTHYRIDIN-2(1H)-ONE(23616-29-7)

Safety Data

• Hazardous Substances Data: 23616-29-7(Hazardous Substances Data)

Usage

General Description

1,6-Naphthyridin-2(1H)-one is a chemical compound with the molecular formula C9H6N2O. It is a heterocyclic compound with a naphthyridine structure, containing a six-membered ring fused to a five-membered ring with a carbonyl group attached to the two-position. 1,6-Naphthyridin-2(1H)-one is of interest in pharmaceutical research due to its potential as a drug target or pharmacophore for drug design. It has been studied for its biological activities, and derivatives of 1,6-Naphthyridin-2(1H)-one have shown promising biological properties, such as antimicrobial and antiviral activities. Furthermore, this compound has also been investigated for its potential as a building block in organic synthesis and as a starting material for the synthesis of other biologically active compounds.

InChI:InChI=1/C8H6N2O/c11-8-2-1-6-5-9-4-3-7(6)10-8/h1-5H,(H,10,11)

Upstream product

• 1721-23-9 2-methyl-nicotinonitrile 
• 127446-43-9 4-<(2,2-Dimethyl-1-oxopropyl)amino>-β-hydroxy-3-pyridinepropanoic Acid, 1,1-Dimethylethyl Ester 
• 88296-61-1 medorinone 
• 104830-01-5 ethyl 4-amino-3-pyridineacrylate 
• 17965-81-0 2-amino-1,6-naphthyridine 
• 253-72-5 1,6-naphthyridine 
• 13534-98-0 3-bromopyridin-4-amine 
• 52600-53-0 5-acetyl-1,2-dihydro-6-methyl-2-oxonicotinonitrile 
• 88877-04-7 1,2-dihydro-5-methyl-2-oxo-1,6-naphthyridine-3-carbonitrile 
• 88877-09-2 1,2-dihydro-5-methyl-2-oxo-1,6-naphthyridine-3-carboxylic acid 
• 88877-02-5 5-acetyl-6-<2-(dimethylamino)ethenyl>-1,2-dihydro-2-oxo-3-pyridinecarbonitrile 

Downstream Products

• 13221-70-0 3-Nitro-1,6-naphthyridin 
• 87992-34-5 2-ethoxy-3-nitro-1,6-naphthyridine 
• 23616-33-3 2-chloro-1,6-naphthyridine 
• 601514-58-3 6-benzyl-5,6,7,8-tetrahydro-[1,6]-naphthyridin-2(1H)-one 
• 766545-20-4 2-chloro-5,6,7,8-tetrahydro[1,6]naphthyridine hydrochloride 
• 1151665-15-4 2-chloro-7,8-dihydro-5H-[1,6]naphthyridine-6-carboxylic acid tert-butyl ester 

Relevant articles and documents

PYRROLO[2,3-C]PYRIDINES AS IMAGING AGENTS FOR NEUROFIBRILARY TANGLES

Pyrrolopyridine compounds of formula (I) or their pharmaceutically acceptable salts are disclosed, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha- synuclein aggregates, and hence are useful in binding and imaging tau aggregates in Alzheimer's patients. More specifically, the compounds are used as tracers in positron emission tomography (PET) imaging to study tau deposits in brain in vivo to allow diagnosis of Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology. Futher, the compounds are useful for measuring clinical efficacy of therapeutic agents for Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology.

A Facile and Novel Synthesis of 1,6-Naphthyridin-2(1H)-ones

A new and convenient procedure for the synthesis of 1,6-naphthyridin-2(1H)-ones and their derivatives is described.In the first scheme 5-acetyl-6--1,2-dihydro-2-oxo-3-pyridinecarbonitrile (4) obtained by the reaction of N,N-dimet

Condensed Heteroaromatic Ring Systems. IV. Synthesis of Naphthyridine Derivatives by Cyclization of Aminopyridineacrylic Esters

The reaction of aminohalopyridines with ethyl acrylate in the presence of palladium(II)acetate and triarylphosphine gave ethyl aminopyridineacrylates.The cyclization of the resulting acrylates under basic conditions gave naphthyridinones having a carbostyril-type moiety.Keywords- intramolecular cyclization; palladium catalyst; ethyl acrylate; naphthyridinone; pyridineacrylic ester