23724-93-8

Basic information

• Product Name: 1-Methoxyisoquinoline
• Synonyms: 1-Methoxyisoquinoline
• CAS NO: 23724-93-8
• Molecular Formula: C10H9 N O
• Molecular Weight: 159.1846
• Mol File: 23724-93-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 271.3°Cat760mmHg
• Flash Point: 99.5°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 0.0108mmHg at 25°C
• Refractive Index: 1.61
• PKA: 3.05±0.20(Predicted)
• CAS DataBase Reference: 1-Methoxyisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Methoxyisoquinoline(23724-93-8)
• EPA Substance Registry System: 1-Methoxyisoquinoline(23724-93-8)

Safety Data

• Hazardous Substances Data: 23724-93-8(Hazardous Substances Data)

Usage

General Description

1-Methoxyisoquinoline is a chemical compound with the molecular formula C10H9NO that consists of an isoquinoline ring system with a methoxy group attached to the 1-position. It is a pale yellow to amber-colored liquid with a boiling point of 256°C. 1-Methoxyisoquinoline is known to have potential pharmacological properties, including antimicrobial, antioxidant, and anti-inflammatory effects. It has been studied for its potential use in the treatment of various medical conditions, such as Alzheimer's disease and cancer. Additionally, 1-Methoxyisoquinoline has been identified as a precursor in the synthesis of other important chemical compounds and pharmaceuticals.

InChI:InChI=1/C10H9NO/c1-12-10-9-5-3-2-4-8(9)6-7-11-10/h2-7H,1H3

Upstream product

• 491-30-5 1-hydroxyisoquinoline 
• 74-88-4 methyl iodide 
• 19493-44-8 1-chloroisoquinoline 
• 124-41-4 sodium methylate 
• 76570-09-7 1-methoxyisoquinoline 2-oxide 
• 115483-69-7 5-Methoxy-1,4-benzothiazepin 
• 2527-57-3 2,2'-dithiobisbenzamide 
• 115483-67-5 1,4-Benzothiazepin-5(4H)-on 
• 115483-66-4 2-(2,2-Diethoxyethylthio)benzamid 
• 55417-70-4 1-chloro isoquinoline N-oxide 

Downstream Products

• 27302-13-2 α-phenyl-1-isoquinolineacetonitrile 
• 4594-71-2 N-methylisocarbostyril 
• 16576-23-1 1-benzoylisoquinoline 

Relevant articles and documents

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On the thermally induced rearrangement of 2-alkoxypyridines to N-alkylpyridones

Analogues of 2-methoxypyridine undergo rearrangement to N-methylpyridones under flash vacuum pyrolysis (FVP) conditions. Ethoxy derivatives undergo competitive ethyl migration and elimination of ethylene. Analogues of 4-methoxypyridine do not undergo rearrangement under FVP conditions, but demethylation on silica may occur. The ease of rearrangement follows the basicity of the alkoxyhetarene to some extent. The vapour-phase rearrangements have been contrasted to condensed-phase pyrolyses. and a four-centre transition state for the former is supported by computation. The rearrangement allows structural assignment to the two products from the reaction of 2,4-dichloroquinoline with pyrrolidine.

Photochemistry of Methoxy-substituted Quinoline and Isoquinoline N-Oxides

The photochemistry of quinoline 1-oxides and isoquinoline 2-oxides bearing a methoxy-group in the pyridine ring was investigated in protic and aprotic media.The formation of various photoisomers, viz. 3,1-benzoxazepines, 2(1H)-quinolones, N-(2-isocyanobenzyl)formamides, 4(1H)-quinolones, and 3-hydroxyquinolines from the different methoxyquinoline 1-oxides, and 1,3-benzoxazepines and 1(2H)-isoquinolones from the different methoxyisoquinoline 2-oxides, was observed along with deoxygenation and formation of products derived from hydration and decomposition of the primary products.The position of the methoxy-group has an important directing effect on the photoreactions.