23750-62-1

Basic information

• Product Name: 1-(2,2-diethoxyethyl)-3-(4-trifluoromethylphenyl)urea
• Synonyms: 1-(2,2-diethoxyethyl)-3-(4-trifluoromethylphenyl)urea
• CAS NO: 23750-62-1
• Molecular Weight: 320.312
• Mol File: 23750-62-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(2,2-diethoxyethyl)-3-(4-trifluoromethylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-diethoxyethyl)-3-(4-trifluoromethylphenyl)urea(23750-62-1)
• EPA Substance Registry System: 1-(2,2-diethoxyethyl)-3-(4-trifluoromethylphenyl)urea(23750-62-1)

Safety Data

• Hazardous Substances Data: 23750-62-1(Hazardous Substances Data)

Upstream product

• 645-36-3 2,2-diethoxy-ethanamine 
• 1548-13-6 p-trifluoromethyl-phenylisocyanate 

Downstream Products

• 155432-09-0 1,3-dihydro-3-[4-(trifluoromethyl)phenyl]-2H-imidazol-2-one 
• 155432-38-5 1-<(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl>-3-(4-trifluoromethylphenyl)-2(1H,3H)-imidazolone 
• 162748-21-2 1-(4-trifluoromethylphenyl)-2-imidazolidinone 

Relevant articles and documents

Optically active antifungal azoles. VIII synthesis and antifungal activity of 1-[(1R,2R)-2-(2,4-difluoro- and 2-fluorophenyl)-2-hydroxy-1- methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4-substituted phenyl)2(1H,3H)- imidazolones and 2-imidazolidinones

New optically active antifungal azoles, 1-[(1R,2R)-2-(2,4-difluoro- and 2-fluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-(4- substituted phenyl)-2(1H,3H)-imidazolones (1, 2) and 2-imidazolidinones (3, 4), were prepared in a stereocontrolled manner from (1S)-1-[(2R)-2-(2,4- difluoro- and 2-fluorophenyl)-2-oxi-ranyl]ethanols (15, 16). Compounds 1 - 4 showed potent antifungal activity against Candida albicans in vitro and in vivo, as well as a broad antifungal spectrum for various fungi in vitro. Furthermore, the imidazolidinones, 3b - e and 4d, e, were found to exert extremely strong growth-inhibitory activity against Aspergillus fumigatus.