23750-76-7

Basic information

• Product Name: 1-(4-Acetyl-phenyl)-3-(4-trifluoromethyl-phenyl)-urea
• Synonyms: 1-(4-Acetyl-phenyl)-3-(4-trifluoromethyl-phenyl)-urea
• CAS NO: 23750-76-7
• Molecular Weight: 322.287
• Mol File: 23750-76-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(4-Acetyl-phenyl)-3-(4-trifluoromethyl-phenyl)-urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Acetyl-phenyl)-3-(4-trifluoromethyl-phenyl)-urea(23750-76-7)
• EPA Substance Registry System: 1-(4-Acetyl-phenyl)-3-(4-trifluoromethyl-phenyl)-urea(23750-76-7)

Safety Data

• Hazardous Substances Data: 23750-76-7(Hazardous Substances Data)

Upstream product

• 99-92-3 p-aminobenzophenone 
• 1548-13-6 p-trifluoromethyl-phenylisocyanate 

Relevant articles and documents

Synthesis of diaryl urea derivatives and evaluation of their antiproliferative activities in colon adenocarcinoma

Colon cancer is one of the leading causes of cancer-related deaths today. Serious research for ideal chemotherapy continues today. In this context, newly synthesized molecules have an essential role in cancer treatment research. The effects of 5 diaryl urea derivatives synthesized within the scope of this study on the HT-29 colon cancer cell line were investigated for the first time in the literature by in-silico and in-vitro methods. Among the five compounds produced in the first stage of the study, DAU5 was found to have a cytotoxic effect on HT-29. However, it was determined that it did not show a serious cytotoxic effect on L929 (healthy fibroblast cell line) at the same doses. The efficacy of DAU5 was evaluated for expression of LC3B, an indicator of autophagy, and 8-OHdG, an indicator of oxidative stress-DNA damage. LC3B and 8-OHdG expression were lower in the DAU5 treatment group than in the control group. As a result, it was seen that DAU5, a diaryl urea derivative compound we synthesized in this study, has the potential to be a chemotherapeutic agent against colon cancer. However, our study needs to be supported by in vivo and clinical studies.

Synthesis and Biological Evaluation of Novel 1-(4-(Hydroxy(1-oxo-1,3-dihydro-2H-inden-2-ylidene)methyl)phenyl)-3-phenylurea Derivatives

A series of novel phenylurea containing 2-benzoylindan-1-one derivatives 3a?–?3j were synthesized from the reaction of phenylurea-substituted acetophenones 1a?–?1j with phthalaldehyde 2 under mild reaction conditions in good yields. All synthesized compou