23756-79-8 Usage
Description
R(+)-SULPIRIDE, also known as the (R)-configuration of sulpiride, is an optically active form of the racemic drug sulpiride. It is the active enantiomer, which means it possesses the desired therapeutic effects while the other enantiomer may have different or no effects. R(+)-SULPIRIDE has potential applications in various industries due to its unique properties.
Uses
Used in Pharmaceutical Industry:
R(+)-SULPIRIDE is used as a therapeutic agent for the treatment of various central nervous system disorders. Its application is based on its ability to selectively bind to dopamine D2 receptors, which can help in managing conditions such as schizophrenia and other related disorders. The use of R(+)-SULPIRIDE in this context is preferred over the racemic mixture due to its higher efficacy and potentially reduced side effects.
Used in Research and Development:
R(+)-SULPIRIDE serves as an important compound in the field of research and development, particularly in the study of enantiomers and their effects on biological systems. Its unique properties allow scientists to investigate the role of stereochemistry in drug action, leading to the development of more effective and safer medications.
Used in Drug Synthesis:
R(+)-SULPIRIDE can be used as a key intermediate in the synthesis of other pharmaceutical compounds. Its optically active nature makes it a valuable building block for the development of new drugs with improved selectivity and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 23756-79-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,7,5 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 23756-79:
(7*2)+(6*3)+(5*7)+(4*5)+(3*6)+(2*7)+(1*9)=128
128 % 10 = 8
So 23756-79-8 is a valid CAS Registry Number.
23756-79-8Relevant articles and documents
A postoperative or its optical isomers of synthetic and post-processing method
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Paragraph 0026; 0027; 0031; 0035, (2018/09/11)
The invention relates to a synthesis and post-processing method of sulpiride or an optical isomer thereof, and the synthesis and post-processing method include the following steps: under inert gas protection, heating 2-methoxy-5-aminosulfonyl methyl benzoate or 2-methoxy-5-aminosulfonyl ethyl benzoate and 1-ethyl-2-aminomethyl pyrrolidine or an optical isomer thereof at 80-120 DEG C for a plurality of hours, and after the reaction is completed, adding ethanol for processing, cooling, filtering, washing and drying.
Synthesis and Inhibitory Activity on Carbonic Anhydrase of Some New Sulpiride Analogues Studied by Means of a New Method
Botre, Claudio,Botre, Francesco,Jommi, Giancarlo,Signorini, Roberto
, p. 1814 - 1820 (2007/10/02)
The pharmacological activity of several new sulpiride analogues was studied by means of a new approach, based on a potentiometric technique with a pCO2 sensor, capable of detecting carbonic anhydrase inhibition at equilibrium conditions.This procedure gives results stated as percent of inhibition of enzymatic activity (IP, inhibitory power).To prove the reliability of the proposed approach and to study structure-activity relationships, several new molecules were synthesized and tested in comparison with the two sulpiride enantiomers.A possible inhibition mechanism is discussed in terms of experimental evidence obtained from the interactions between the molecular structures of the new synthesized compounds and carbonic anhydrase.
