2387-20-4

Basic information

• Product Name: 1-(2-Chloroethyl)imidazolidin-2-one
• Synonyms: 1-(2-chloroethyl)imidazolidin-2-one;N-(2-Chloroethyl)imidazolidinone;1-(2-Chloroethyl)iMidazolidine-2-one;N-(β-Chloroethyl)-N,N'-ethyleneurea;NSC 76791
• CAS NO: 2387-20-4
• Molecular Formula: C₅H₉ClN₂O
• Molecular Weight: 148.59
• EINECS: 219-212-1
• Product Categories: Heterocycles
• Mol File: 2387-20-4.mol
• Article Data: 8

Chemical Properties

• Melting Point: 85-85 °C(Solv: acetone (67-64-1); carbon tetrachloride (56-23-5))
• Boiling Point: 347.5 °C at 760 mmHg
• Flash Point: 164 °C
• Appearance: /
• Density: 1.225 g/cm³
• Vapor Pressure: 5.36E-05mmHg at 25°C
• Refractive Index: 1.489
• PKA: 14.31±0.20(Predicted)
• CAS DataBase Reference: 1-(2-Chloroethyl)imidazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Chloroethyl)imidazolidin-2-one(2387-20-4)
• EPA Substance Registry System: 1-(2-Chloroethyl)imidazolidin-2-one(2387-20-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 2387-20-4(Hazardous Substances Data)

Usage

Description

1-(2-Chloroethyl)imidazolidin-2-one, also known as 1-(2-Chloroethyl)-2-imidazolidinone (CAS# 2387-20-4), is an organic compound with a unique chemical structure that features a chloroethyl group attached to an imidazolidinone ring. 1-(2-Chloroethyl)imidazolidin-2-one is known for its versatile reactivity and potential applications in various fields due to its chemical properties.

Uses

Used in Organic Synthesis:
1-(2-Chloroethyl)imidazolidin-2-one is used as a synthetic building block for the creation of various organic compounds. Its unique structure allows it to be a valuable intermediate in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. The presence of the chloroethyl group and the imidazolidinone ring in the molecule makes it a versatile and reactive component in organic synthesis processes.
Used in Pharmaceutical Industry:
1-(2-Chloroethyl)imidazolidin-2-one is used as a key intermediate in the development of new drugs for various therapeutic applications. Its reactivity and structural features make it a promising candidate for the design and synthesis of novel pharmaceutical compounds with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(2-Chloroethyl)imidazolidin-2-one is used as a starting material for the synthesis of new pesticides, herbicides, and other crop protection agents. Its unique chemical properties enable the development of innovative and effective products to address the challenges faced by the agricultural sector.
Used in Specialty Chemicals:
1-(2-Chloroethyl)imidazolidin-2-one is also utilized in the production of specialty chemicals, such as dyes, additives, and coatings. Its versatility in organic synthesis allows for the creation of a wide range of products with specific properties tailored to various industrial applications.

InChI:InChI=1/C5H9ClN2O/c6-1-3-8-4-2-7-5(8)9/h1-4H2,(H,7,9)

Upstream product

• 3699-54-5 2-oxo-imidazolidine-1-ethanol 
• 98070-00-9 1-(2-nitroamino-ethyl)-imidazolidin-2-one 
• 154-93-8 1,3-bis(2-chloroethyl)-1-nitrosourea 

Downstream Products

• 109099-94-7 1-(2-benzylamino-ethyl)-imidazolidin-2-one; hydrochloride 
• 4971-43-1 N-(vinyl)-2-imidazolidinone 
• 6281-42-1 2-aminoethylimidazolidone 
• 116842-60-5 1-<2-(4-benzyl-1-piperazinyl)ethyl>-2-imidazolidinone 
• 106516-21-6 Lu 23-086 
• 138923-84-9 1-(2-{4-[1-(4-Fluoro-phenyl)-5-methyl-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one 
• 138900-31-9 1-(2-{4-[5-Fluoro-1-(4-fluoro-phenyl)-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one 
• 138900-32-0 1-[2-[4-[5-bromo-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2-imidazolidinone 
• 138900-26-2 1-(2-{4-[5-cyano-1-(4-fluorophenyl)-1H-indol-3-yl]-1,2,3,6-tetrahydropyridin-1-yl}ethyl)-2-imidazolidinone 
• 138900-37-5 1-(4-fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-4-piperidyl]-5-methoxy-1H-indole 
• 138900-34-2 1-(2-{4-[5-cyano-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl}ethyl)-2-imidazolidinone 
• 106516-55-6 1-(4-Fluorophenyl)-3-[1-[2-(2-imidazolidinon-1-yl)ethyl]-1,2,3,6-tetrahydropyridin-4-yl]-5-trifluoromethyl-1H-indole 
• 138900-33-1 1-(2-{4-[1-(4-Fluoro-phenyl)-5-trifluoromethyl-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one 
• 138900-35-3 1-(2-{4-[1-(4-Fluoro-phenyl)-5-methanesulfonyl-1H-indol-3-yl]-piperidin-1-yl}-ethyl)-imidazolidin-2-one 

Relevant articles and documents

Ionic-Liquid-Supported 1,3-Dimethylimidazolidin-2-one: Application as a Reusable Halogenation Reagent

We describe the synthesis of ionic-liquid-supported 1,3-dimethylimidazolidin-2-one, together with the halogenation of alcohols in a reaction system in which this reagent is combined with oxalyl chloride. A new method was established that does not require additives such as bases, and which permits the ready isolation and purification of the product. Good conversions were obtained, and good reusability of the reagent was observed.

Graft polymer to which combined nitrogen molecules are grafted

The present invention relates to a modified polymer obtained by grafting of a compound comprising at least one group Q and at least one group A, bonded together by at least, and preferably, one “spacer” group Sp in which: Q comprises a dipole containing at least, and preferably, one nitrogen atom, capable of being grafted onto the polymer chain by [1,3]-dipolar cycloaddition,A comprises an associative group comprising at least one nitrogen atom,Sp is an atom or a group of atoms forming a bond between Q and A.

Tyrosine kinase inhibitors

The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.