23903-57-3

Basic information

• Product Name: Dihydroorotate Acid Methyl Ester
• Synonyms: Dihydroorotate Acid Methyl Ester;methyl 2,6-dioxo-hexahydropyrimidine-4-carboxylate
• CAS NO: 23903-57-3
• Molecular Formula: C6H8N2O4
• Molecular Weight: 172.13872
• Product Categories: Heterocycles, Miscellaneous Reagents
• Mol File: 23903-57-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.333±0.06 g/cm3(Predicted)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.20±0.40(Predicted)
• CAS DataBase Reference: Dihydroorotate Acid Methyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Dihydroorotate Acid Methyl Ester(23903-57-3)
• EPA Substance Registry System: Dihydroorotate Acid Methyl Ester(23903-57-3)

Safety Data

• Hazardous Substances Data: 23903-57-3(Hazardous Substances Data)

Usage

Description

Dihydroorotate Acid Methyl Ester is a chemical reagent that specifically interacts with the dihydroorotate dehydrogenase enzyme found in bovine liver mitochondria. This interaction makes it a valuable compound for research purposes, particularly in the study of dihydroorotate dehydrogenase (DHODH) and its role in various biological processes.

Uses

Used in Research Applications:
Dihydroorotate Acid Methyl Ester is used as a chemical reagent for dihydroorotate dehydrogenase (DHODH) related research. It serves as a valuable tool for scientists to investigate the function and regulation of DHODH enzyme, which plays a crucial role in the de novo pyrimidine biosynthesis pathway.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Dihydroorotate Acid Methyl Ester is utilized as a starting material or intermediate in the synthesis of various drugs targeting DHODH enzyme. Inhibiting DHODH has been shown to have potential therapeutic benefits in treating certain diseases, making this compound an important component in drug development processes.
Used in Biochemical Assays:
Dihydroorotate Acid Methyl Ester is also employed in biochemical assays to measure the activity of DHODH enzyme. By using this compound as a substrate, researchers can accurately determine the enzyme's activity levels, which can be useful in understanding its role in various biological processes and disease states.
Overall, Dihydroorotate Acid Methyl Ester is a versatile chemical reagent with applications in research, pharmaceutical development, and biochemical assays, all centered around the study and manipulation of the dihydroorotate dehydrogenase enzyme.

Upstream product

• 116393-69-2 methyl N³-benzyloxymethyl-5,6-dihydroorotate 
• 155-54-4 4,5-dihydroorotic acid 
• 116393-68-1 methyl N¹,N³-dibenzyloxymethyl-5,6-dihydroorotate 

Relevant articles and documents

-

-

2-Oxo-4-carboxy-pyrimidines

A compound for use as an inhibitor for the enzyme dihydroorotase and which is of general formula (I) where either (i) A and B together are =S, or (ii) A is -H, and B is -COR2 or -SR6; and, R1 and R2 which may be the same or different are -OH; alkyloxymethyl, a di-, tri- or polypeptide group, -OR where R is saturated or unsaturated C1-16alkyl, C1-16alkyloxymethyl, or 4-alkyl-piperidinyl-alkyl, -NR′R′ where each R′ is independently selected from -H, saturated or unsaturated C1-16alkyl, or any group able to be hydrolysed in vivoto hydroxy;, R3 and R4 which may be the same or different are -H, C1-6alkyl, hydroxy C1-16alkyl, hydroxy C1-6ether group, tetrahydrofuranyl, tetrahydropyranyl, a sugar or acetylated sugar group, hexylcarbamyl, methylglycine-N-carbonyl, or any group able to be hydrolysed in vivoto -H;, R5 is -H, halo, or C1-6alkyl;, R6 is C1-6alkyl or 1-methyl-4-nitroimidazol-5-yl; and the dotted line represents a double bond which may be absent or present in the 4-5 position. The compounds are useful as anti-cancer and anti-malarial drugs.