23995-88-2

Basic information

• Product Name: 1-(1-Methyl-4-piperidinyl)piperazine
• Synonyms: RARECHEM AH CK 0142;BUTTPARK 82\08-46;1-METHYL-4-PIPERAZINOPIPERIDINE;1-(N-METHYL-PIPERIDIN-4-YL)PIPERAZINE;1-(1-METHYL-PIPERIDIN-4-YL)-PIPERAZINE;1-(1-METHYL-4-PIPERIDINYL)PIPERAZINE;Piperazine, 1-(1-methyl-4-piperidinyl)- (9CI);1-(1-METHYL-PIPERIDIN-4-YL)-PIPERAZINE >98%
• CAS NO: 23995-88-2
• Molecular Formula: C₁₀H₂₁N₃
• Molecular Weight: 183.29
• Product Categories: PIPERIDINE;API intermediates;piperazines
• Mol File: 23995-88-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 29-32℃
• Boiling Point: 99°C/0.08mm
• Flash Point: 113.2 °C
• Appearance: Clear colorless to slightly yellow/Liquid
• Density: 0.992 g/cm3
• Vapor Pressure: 0.0124mmHg at 25°C
• Refractive Index: n20/D 1.508
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
• PKA: 9.28±0.10(Predicted)
• Sensitive: Air Sensitive
• CAS DataBase Reference: 1-(1-Methyl-4-piperidinyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-Methyl-4-piperidinyl)piperazine(23995-88-2)
• EPA Substance Registry System: 1-(1-Methyl-4-piperidinyl)piperazine(23995-88-2)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 3
• F: 10-34
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 23995-88-2(Hazardous Substances Data)

Usage

Description

1-(1-Methyl-4-piperidinyl)piperazine is an organic compound with the molecular formula C10H21N3. It is a heterocyclic compound featuring a piperidine ring with a methyl group and a piperazine ring. 1-(1-Methyl-4-piperidinyl)piperazine is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
1-(1-Methyl-4-piperidinyl)piperazine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs with specific therapeutic properties.
Used in Chemical Industry:
1-(1-Methyl-4-piperidinyl)piperazine is used as a building block for the preparation of complex organic molecules, particularly in the synthesis of Pyrazolo Estratrienes. These compounds serve as inhibitors of 17-HSD1, an enzyme involved in the synthesis of sex hormones. By targeting this enzyme, Pyrazolo Estratrienes have potential applications in the treatment of hormone-related disorders and cancers.

InChI:InChI=1/C10H21N3/c1-12-6-2-10(3-7-12)13-8-4-11-5-9-13/h10-11H,2-9H2,1H3

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 2759-28-6 1-phenylmethylpiperazine 

Downstream Products

• 416867-97-5 1-(1-methylpiperidin-4-yl)-4-(4-nitrophenyl)piperazine 
• 1017275-66-9 {4-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-phenyl}-acetonitrile 
• 873955-76-1 4-(1-methyl-piperidin-4-yl)-piperazine-1-carboxylic acid [5-methoxy-2-oxo-3-(2-propoxy-phenyl)-2,3-dihydro-1H-indol-3-yl]-ester 
• 1018820-22-8 2-[1-(4-methoxy-2,6-dimethyl-phenylsulfonyl)-piperidin-2-ylmethoxy]-1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-ethanone 
• 1018820-19-3 1-[4-(1-methyl-piperidin-4-yl)-piperazin-1-yl]-2-[2-(2,4,6-trimethyl-phenylsulfonyl)-1,2,3,4-tetrahydro-isoquinolin-3-ylmethoxy]-ethanone 
• 1018821-60-7 (S)-2-((2-(4-methoxy-2,6-dimethylphenylsulfonyl)-1,2,3,4-tetrahydroisoquinolin-3-yl)-methoxy)-1-(4-(1-methylpiperidin-4-yl)piperazin-1-yl)ethanone 

Relevant articles and documents

2-amino-4-substituted pyridine derivative as well as synthesis method and application thereof

The invention discloses a 2-amino-4-substituted pyridine derivative as well as a synthesis method and an application thereof. The derivative with the structural formula is a compound with the structure or pharmacologically acceptable salt, hydrate, solvate, polymorphic substance, tautomer, stereoisomer, isotope derivative or prodrug of the compound. The 2-amino-4-substituted pyridine derivative has higher EGFR (epidermal growth factor receptor) inhibition activity, has higher inhibition activity for human epidermal cell carcinoma cells, glioblastoma cells and the like and can be used for preparing drugs for treating and/or preventing and/or delaying and/or assisting in treatment and/or treatment of diseases related with too high EGFR activity.