240139-82-6

Basic information

• Product Name: 2-METHOXY-5-TRIFLUOROMETHYLPHENYLBORONIC ACID
• Synonyms: AKOS BRN-0194;2-METHOXY-5-TRIFLUOROMETHYLPHENYLBORONIC ACID;2-METHOXY-5-(TRIFLUOROMETHYL)BENZENEBORONIC ACID;5-(trifluoroMethyl)-2-Methoxyphenylboronic acid;Boronic acid,B-[2-Methoxy-5-(trifluoroMethyl)phenyl]-;3-Borono-4-methoxybenzotrifluoride
• CAS NO: 240139-82-6
• Molecular Formula: C₈H₈BF₃O₃
• Molecular Weight: 219.95
• Product Categories: blocks;BoronicAcids;FluoroCompounds;Boronic Acids & Esters;Phenyls & Phenyl-Het;Boronic Acids & Esters;Phenyls & Phenyl-Het;Aryl;Organoborons;Aryl Boronic Acids;Boronic Acids;Boronic Acids and Derivatives;Chemical Synthesis;Disubstituted Aryl Boronic Acids;New Products for Chemical Synthesis;Organometallic Reagents;Boronate Ester;Boronic Acid;Potassium Trifluoroborate
• Mol File: 240139-82-6.mol
• Article Data: 3

Chemical Properties

• Melting Point: 144-148℃
• Boiling Point: 325.4 °C at 760 mmHg
• Flash Point: 150.6 °C
• Appearance: /
• Density: 1.36 g/cm³
• Vapor Pressure: 9.44E-05mmHg at 25°C
• Refractive Index: 1.464
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 7.57±0.58(Predicted)
• CAS DataBase Reference: 2-METHOXY-5-TRIFLUOROMETHYLPHENYLBORONIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-5-TRIFLUOROMETHYLPHENYLBORONIC ACID(240139-82-6)
• EPA Substance Registry System: 2-METHOXY-5-TRIFLUOROMETHYLPHENYLBORONIC ACID(240139-82-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• HazardClass: IRRITANT
• Hazardous Substances Data: 240139-82-6(Hazardous Substances Data)

Usage

Uses

suzuki reaction

InChI:InChI=1/C8H8BF3O3/c1-15-7-3-2-5(8(10,11)12)4-6(7)9(13)14/h2-4,13-14H,1H3

Upstream product

• 402-52-8 methyl 4-(trifluoromethyl)phenyl ether 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 402-10-8 2-bromo-1-methoxy-4-(trifluoromethyl)benzene 

Downstream Products

• 349-67-7 2-methoxy-5-(trifluoromethyl)phenol 
• 1003297-71-9 3-(2-methoxy-5-trifluoromethyl-phenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine 
• 1354819-20-7 2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenol 
• 1354819-24-1 4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 
• 1354818-84-0 4-[2-(2-aminopyridin-4-yl)-4-(trifluoromethyl)phenoxy]-5-chloro-2-fluoro-N-(5-fluoropyrimidin-2-yl)benzenesulfonamide 4-methylbenzenesulfonate 
• 1448857-86-0 2-(hex-5-en-1-yloxy)-5-(2-methoxy-5-(trifluoromethyl)phenyl)-1-methyl-1H-imidazole 

Relevant articles and documents

New 5-aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting

We designed and synthesized 48 aryl-1H-imidazole derivatives and investigated their in vitro growth inhibitory activity in cancer cell lines known to present various levels of resistance to proapoptotic stimuli. The IC50 in vitro growth inhibitory concentration of these compounds ranged from >100 μM to single digit μM. Among the most active compounds, 2i displayed similar in vitro growth inhibition in cancer cells independent of the cells' levels of resistance to proapoptotic stimuli and was found to be cytostatic in melanoma cell lines. Compound 2i was then tested by the National Cancer Institute Human Tumor Cell Line Anti-Cancer Drug Screen, and the NCI COMPARE algorithm did not reveal any correlation between its growth inhibition profiles with the NCI database compound profiles. The use of transcriptomically characterized melanoma models then enabled us to highlight mitochondrial targeting by 2i. This hypothesis was further confirmed by reactive oxygen production measurement and oxygen consumption analysis.

Novel compounds and their use as positive AMPA receptor modulators

The invention provides novel compounds represented by the general formula 5 compound represented by the formula: wherein the bond represented by the broken line may be a single, a double bond or absent; and if the bond is absent, then the nitrogen is substituted with a hydrogen and R2; X represents SO2 or C═O or CH2; Y represents —CH(R4)—, —N(R4)— or —N(R4)—CH2—, O; and the meaning of R2, R3, R4, R5, R6, R7, and R8 are as defined in the application The compounds are useful as positive modulators of the AMPA-receptor.