2403-27-2

Basic information

• Product Name: (2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one
• Synonyms: (2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one;1-(4-Bromophenyl)-3-phenyl-2-propen-1-one;4-Bromophenylstyryl ketone;Styryl(4-bromophenyl) ketone;β-Phenyl-4'-bromoacrylophenone;2-Propen-1-one, 1-(4-bromophenyl)-3-phenyl-;Ai3-16122;Ccris 2220
• CAS NO: 2403-27-2
• Molecular Formula: C₁₅H₁₁BrO
• Molecular Weight: 287.16
• Product Categories: Halides;Phenyls & Phenyl-Het
• Mol File: 2403-27-2.mol
• Article Data: 169

Chemical Properties

• Boiling Point: 402.2°Cat760mmHg
• Flash Point: 82.4°C
• Appearance: /
• Density: 1.393g/cm³
• Vapor Pressure: 1.12E-06mmHg at 25°C
• Refractive Index: 1.646
• CAS DataBase Reference: (2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one(2403-27-2)
• EPA Substance Registry System: (2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one(2403-27-2)

Safety Data

• Hazardous Substances Data: 2403-27-2(Hazardous Substances Data)

Usage

Description

(2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one, also known as 4'-bromoacetophenone, is an organic compound with a molecular formula of C15H11BrO. It is categorized as a ketone and contains a benzene ring with a bromine atom and a phenyl group attached to a carbon-carbon double bond. (2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one is significant in the field of organic chemistry and drug development.

Uses

Used in Pharmaceutical Industry:
(2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one is used as a precursor in the synthesis of various pharmaceuticals for its ability to be a building block in creating complex molecules.
Used in Agrochemical Industry:
(2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one is used as a precursor in the synthesis of various agrochemicals, contributing to the development of new compounds for agricultural applications.
Used in Organic Synthesis:
(2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one is used as a building block in organic synthesis for creating complex molecules, showcasing its versatility in chemical reactions.
Used in Biological and Pharmacological Research:
(2E)-1-(4-bromophenyl)-3-phenylprop-2-en-1-one is utilized in research for its potential biological and pharmacological activities, indicating its importance in scientific studies and drug discovery.

InChI:InChI=1/C15H11BrO/c16-14-9-7-13(8-10-14)15(17)11-6-12-4-2-1-3-5-12/h1-11H/b11-6+

Upstream product

• 99-90-1 para-bromoacetophenone 
• 100-52-7 benzaldehyde 
• 75-15-0 carbon disulfide 
• 7446-70-0 aluminium trichloride 
• 108-86-1 bromobenzene 
• 102-92-1 Cinnamoyl chloride 
• 102-92-1 cinnamoyl chloride 
• 65679-14-3 1-(4-bromophenyl)-2-thiocyanatoethanone 
• 86668-29-3 4-(3-phenylallyl)bromobenzene 
• 100-42-5 styrene 
• 201230-82-2 carbon monoxide 
• 589-87-7 1,4-bromoiodobenzene 
• 19710-56-6 hydroxycarbene 
• 5467-74-3 4-Bromophenylboronic acid 

Downstream Products

• 6271-51-8 2,3-dibromo-1-(4-bromo-phenyl)-3-phenyl-propan-1-one 
• 20822-01-9 3-(4-bromophenyl)-5-phenyl-4,5-dihydro-isoxazole 
• 909081-00-1 [3-(4-bromo-phenyl)-3-oxo-1-phenyl-propyl]-malonic acid dimethyl ester 
• 102752-32-9 diethyl 2-(3-(4-bromophenyl)-3-oxo-1-phenylpropyl)malonate 
• 96266-14-7 1-(4-bromo-phenyl)-4-nitro-3,4-diphenyl-butan-1-one 
• 43008-85-1 1-(4-bromophenyl)-3-phenylpropane 
• 108325-92-4 (4-Bromo-phenyl)-(4-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-methanone 
• 121582-00-1 5-(4-Bromo-phenyl)-7-phenyl-4,7-dihydro-tetrazolo[1,5-a]pyrimidine 
• 74007-55-9 1-(4-Bromo-phenyl)-3,3-dimethoxy-2-phenyl-propan-1-one 
• 101854-96-0 1-(4-bromo-phenyl)-3-methoxyamino-3-phenyl-propan-1-one 
• 113854-31-2 6-(4-Bromo-phenyl)-3-methyl-1,4-diphenyl-4,5-dihydro-1H-pyrazolo[3,4-b]pyridine 
• 86516-92-9 6-(4-Bromo-phenyl)-1,3-dimethyl-8-phenyl-7,8-dihydro-1H-pyrimido[4,5-b][1,4]oxazepine-2,4-dione 
• 111336-87-9 5-(4-Bromo-phenyl)-3-methyl-1,7-diphenyl-1,6,7,8-tetrahydro-pyrazolo[3,4-b][1,4]diazepine 
• 94360-62-0 (2R,3S)-2-(4-Bromo-benzoyl)-3-phenyl-cyclopropane-1,1-dicarbonitrile 

Relevant articles and documents

Diastereoselective 1,3-dioxolane formation by photocatalytic ring opening of a-epoxyketones

Photocatalytic ring opening of α-epoxyketones by 2,3-dichloro-5,6- dicyano-1,4-benzoquinone (DDQ) in acetone resulted in the diastereoselective formation of 1,3-dioxolanes through Cα-O bond cleavage. The facility of the ring opening is influenced by the nature and the location of the additional substituent on the α-epoxyketones.

Pyridoimidazole derivatives as well as preparation method and application thereof

The invention discloses pyridoimidazole derivatives as well as a preparation method and application thereof. The pyridoimidazole derivatives with two D-pi-A structures are synthesized on the basis that pyridoimidazole serves as an electron acceptor system by means of the electron donating property of phenanthroimidazole/diphenylamine. The pyridoimidazole derivatives can serve as photoinitiators, and the two photoinitiators both have longer conjugated chain lengths, so that the photon absorption cross section is increased, the photoinitiators can initiate polymerization reaction at the wavelength of 365 nm, have higher polymerization efficiency, and can be widely applied to the field of ultraviolet curing.

Mechanochemical Syntheses of N-Containing Heterocycles with TosMIC

A mechanochemical van Leusen pyrrole synthesis with a base leads to 3,4-disubstitued pyrroles in moderate to excellent yields. The developed protocol is compatible with a range of electron-withdrawing groups and can also be applied to the synthesis of oxazoles. Attempts to mechanochemically convert the resulting pyrroles into porphyrins proved to be difficult.

Synthesis and antimicrobial evaluation of arylated 1,3,5-triphenyl pyrazoline derivatives using suzuki-miyaura reactions

The first palladium –catalyzed coupling reactions of 1,3,5-triphenyl pyrazoline are reported. The Suzuki-Miyaura reaction of 3-(4-bromophenyl)-1,5-diphenyl pyrazoline with one equivalent of arylboronic acids afforded 3-(biphenyl)-1,5-diphenyl pyrazoline in 53-78 % yield. While the Suzuki-Miyaura reactions of 3,5-bis(4-bromophenyl)-1-phenyl pyrazoline with two equivalent of arylboronic acids gave 3,5-bis(biphenyl)-1-phenyl pyrazoline in 55-80% yield. The characterization of the synthesized derivatives (5a-h) and (6a-h) were accomplished on the basis of NMR, FT-IR, and mass techniques. The newly pyrazoline derivatives have been investigated for their in vitro antibacterial activity against gram- negative and gram-positive bacteria. The di-coupling compounds (6a-h) exhibited promising antibacterial against all four bacterial strains compared to the mono-coupling compounds (5a-h) which displayed a slight activity. The compound 6d showed a potent activity significantly more active than Trimethoprim (100μg/ml).