24059-83-4

Basic information

• Product Name: 3-METHOXYPICOLINIC ACID METHYL ESTER
• Synonyms: 2-PYRIDINECARBOXYLIC ACID, 3-METHOXY-, METHYL ESTER;3-METHOXYPICOLINIC ACID METHYL ESTER;3-Methoxy-pyridine-2-carboxylic acid methyl ester;Methyl 3-methoxypyridine-2-carboxylate;methyl 3-methoxypicolinate;3-Methoxy-pyridin-2-carboxylic acid methyl ester
• CAS NO: 24059-83-4
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• Product Categories: Heterocycles;Heterocycle-Pyridine series
• Mol File: 24059-83-4.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 280.4 °C at 760 mmHg
• Flash Point: 123.4 °C
• Appearance: /
• Density: 1.156 g/cm³
• Vapor Pressure: 0.0038mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.16±0.10(Predicted)
• CAS DataBase Reference: 3-METHOXYPICOLINIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXYPICOLINIC ACID METHYL ESTER(24059-83-4)
• EPA Substance Registry System: 3-METHOXYPICOLINIC ACID METHYL ESTER(24059-83-4)

Safety Data

• Hazardous Substances Data: 24059-83-4(Hazardous Substances Data)

Usage

General Description

3-Methoxypicolinic acid methyl ester is a chemical compound with the molecular formula C8H9NO3. It is a methyl ester form of 3-methoxypicolinic acid, which is used in the synthesis of various pharmaceutical and organic compounds. This chemical can be utilized as a building block in the production of drug molecules, such as antiviral and antitumor agents. It also has potential applications in the field of agricultural chemistry and as a precursor in organic synthesis.3-Methoxypicolinic acid methyl ester is an important intermediate in the creation of diverse chemical compounds and has potential utility in various industries.

InChI:InChI=1/C8H9NO3/c1-11-6-4-3-5-9-7(6)8(10)12-2/h3-5H,1-2H3

Upstream product

• 874-24-8 3-hydroxypyridine-2-carboxylic acid 
• 74-88-4 methyl iodide 
• 62733-99-7 methyl 3-hydroxypicolinate 
• 67-56-1 methanol 
• 16478-52-7 3-methoxypyridine-2-carboxylic acid 

Downstream Products

• 16478-52-7 3-methoxypyridine-2-carboxylic acid 
• 884501-76-2 1-(4-methoxyphenyl)-3-(3-methoxypyridin-2-yl)propane-1,3-dione 
• 1349179-60-7 C₁₈H₁₈BrF₂N₃O₄S 
• 945954-94-9 methyl 6-bromo-3-methoxypyridine-2-carboxylate 
• 884500-73-6 2-(4-hydroxyphenyl)-4H-pyrano[3,2-b]pyridin-4-one 

Relevant articles and documents

POLYCYCLIC AMIDES AS UBE2K MODULATORS FOR TREATING CANCER

Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating conditions associated with modulation of UBE2K.

RORγ MODULATORS

The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.

N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists

The nuclear retinoic acid receptor-related orphan receptor γ (RORγ; NR1F3) is a key regulator of inflammatory gene programs involved in T helper 17 (TH17) cell proliferation. As such, synthetic small-molecule repressors (inverse agonists) targeting RORγ have been extensively studied for their potential as therapeutic agents for various autoimmune diseases. Alternatively, enhancing TH17 cell proliferation through activation (agonism) of RORγ may boost an immune response, thereby offering a potentially new approach in cancer immunotherapy. Herein we describe the development of N-arylsulfonyl indolines as RORγ agonists. Structure–activity studies reveal a critical linker region in these molecules as the major determinant for agonism. Hydrogen/deuterium exchange coupled to mass spectrometry (HDX-MS) analysis of RORγ–ligand complexes help rationalize the observed results.