24097-17-4

Basic information

• Product Name: 3-(4-Chlorophenyl)-5-phenylisoxazole
• Synonyms: 3-(4-Chlorophenyl)-5-phenylisoxazole;3-(p-Chlorophenyl)-5-phenylisoxazole
• CAS NO: 24097-17-4
• Molecular Formula: C₁₅H₁₀ClNO
• Molecular Weight: 255.699
• Mol File: 24097-17-4.mol
• Article Data: 25

Chemical Properties

• Melting Point: 178-179 °C
• Boiling Point: 421.5°Cat760mmHg
• Flash Point: 208.7°C
• Appearance: /
• Density: 1.229g/cm³
• Vapor Pressure: 6.35E-07mmHg at 25°C
• Refractive Index: 1.595
• PKA: -3.34±0.25(Predicted)
• CAS DataBase Reference: 3-(4-Chlorophenyl)-5-phenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Chlorophenyl)-5-phenylisoxazole(24097-17-4)
• EPA Substance Registry System: 3-(4-Chlorophenyl)-5-phenylisoxazole(24097-17-4)

Safety Data

• Hazardous Substances Data: 24097-17-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H10ClNO/c16-13-8-6-11(7-9-13)14-10-15(18-17-14)12-4-2-1-3-5-12/h1-10H

Upstream product

• 32897-40-8 N-methyl-N-(1-phenylethenyl)aniline 
• 28123-63-9 4-chlorobenzohydroximoyl chloride 
• 1004-22-4 (phenylethynyl)sodium 
• 14764-45-5 [3-(4-chloro-phenyl)-5-phenyl-isoxazol-4-yl]-phenyl-methanone 
• 98783-25-6 4-[3-(4-chloro-phenyl)-5-phenyl-4,5-dihydro-isoxazol-5-yl]-morpholine 
• 5447-87-0 2-(1-phenylethylidene)propanedinitrile 
• 17059-59-5 1-(4-chloro-phenyl)-3-phenyl-propane-1,3-dione 
• 132603-61-3 (Z)-3-(4-Chloro-phenyl)-3-[hydroxy-(hydroxy-phenyl-methyl)-amino]-1-phenyl-propen-1-ol 
• 112853-65-3 (4S,5R)-3-(4-Chloro-phenyl)-4-nitro-5-phenyl-4,5-dihydro-isoxazole 
• 5468-44-0 α-nitrostyrene 
• 15500-74-0 4-chlorobenzonitrile N-oxide 
• 112853-65-3 (4S,5S)-3-(4-Chloro-phenyl)-4-nitro-5-phenyl-4,5-dihydro-isoxazole 
• 22966-22-9 (E)-1-(4-chlorophenyl)-3-phenyl-2-propen-1-one 
• 132603-57-7 (Z)-3-(4-Chloro-phenyl)-3-hydroxyamino-1-phenyl-propen-1-ol 

Downstream Products

• 31554-59-3 4-chloro-3-(4-chlorophenyl)-5-phenylisoxazole 
• 80223-04-7 3-(4-Chloro-phenyl)-2-methyl-5-phenyl-isoxazol-2-ium; iodide 
• 85231-86-3 [4-(4-Chloro-phenyl)-[1,2,5]thiadiazol-3-yl]-phenyl-methanone 

Relevant articles and documents

TEMPO-Mediated Selective Synthesis of Isoxazolines, 5-Hydroxy-2-isoxazolines, and Isoxazoles via Aliphatic δ-C(sp3)-H Bond Oxidation of Oximes

Selective synthesis of three different bioactive heterocycles; isoxazolines, 5-hydroxy-2-isoxazolines and isoxazoles from the same starting material using TEMPO (2,2,6,6-Tetramethylpiperidin-1-oxyl) as a radical initiator is reported. Selectivity was achi

3, 5-disubstituted isoxazole derivative and synthesis method thereof

The invention provides a 3, 5-disubstituted isoxazole derivative and a synthesis method thereof, and belongs to the technical field of organic synthesis medicines and medical intermediates. The method comprises the following steps: adding a proper solvent

Catalyst control in positional-selective C-H alkenylation of isoxazoles and a ruthenium-mediated assembly of trisubstituted pyrroles

High levels of catalyst control are demonstrated in determining the positional selectivity in C-H alkenylation of isoxazoles. A cationic rhodium-mediated, strong-directing group promotes C(sp2)-H activation at the proximal aryl ring whereas, the palladium-mediated electrophilic metallation leads to the C(sp2)-H activation at the distal position of the directing group. Synthetic elaboration of this C-H alkenylation product via ruthenium and copper co-catalysis leads to an efficient method for the assembly of densely substituted pyrroles.