24125-16-4

Basic information

• Product Name: LEUPEPTIN HYDROCHLORIDE
• Synonyms: ACETYL-LEU-LEU-ARG-AL HCL;ACETYL-LEU-LEU-ARG-AL HYDROCHLORIDE;LEUPEPTIN HYDROCHLORIDE;leupeptin hydrochloride from*microbial source;LEUPEPTIN HYDROCHLORIDE, HIGH PURITY;L-Leucinamide, N-acetyl-L-leucyl-N-4-(aminoiminomethyl)amino-1-formylbutyl-, monohydrochloride;Leupeptin hydrochloride >90%;(S)-2-acetaMido-N-((S)-1-(((S)-5-guanidino-1-oxopentan-2-yl)aMino)-4-Methyl-1-oxopentan-2-yl)-4-MethylpentanaMide hydrochloride
• CAS NO: 24125-16-4
• Molecular Formula: C20H39ClN6O4
• Molecular Weight: 463.01
• Product Categories: Miscellaneous Peptides;Aldehydes;and Substrates;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Carbonyl Compounds;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Enzyme Inhibitors;Enzymes;Inhibitors;L;Organic Building Blocks;Peptides and Proteins;Peptides for Cell Biology;Protease Inhibitors;Pepetides;peptides;inhibitor
• Mol File: 24125-16-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 734.4°C at 760 mmHg
• Flash Point: 398°C
• Appearance: solid
• Vapor Pressure: 7.31E-22mmHg at 25°C
• Storage Temp.: −20°C
• Stability: Stable, but store cold. Incompatible with strong bases, strong acids.
• CAS DataBase Reference: LEUPEPTIN HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: LEUPEPTIN HYDROCHLORIDE(24125-16-4)
• EPA Substance Registry System: LEUPEPTIN HYDROCHLORIDE(24125-16-4)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• Hazardous Substances Data: 24125-16-4(Hazardous Substances Data)

Usage

Description

Leupeptin Hydrochloride is a potent protease inhibitor derived from the actinomycete Amycolatopsis mediterranei. It is a white to off-white crystalline solid that exhibits strong inhibitory effects on various proteolytic enzymes, including trypsin, plasmin, and thrombin. Its chemical properties and ability to inhibit proteases make it a valuable compound for research and therapeutic applications.

Uses

Used in Research Applications:
Leupeptin Hydrochloride is used as a research tool for the characterization of macroautophagic flux in vivo using leupeptin-based assays. It helps in understanding the process of autophagy, which is a cellular mechanism for the degradation and recycling of damaged or unnecessary cellular components.
Used in Pharmaceutical Industry:
Leupeptin Hydrochloride is used as a protease inhibitor for the development of therapeutic agents targeting various diseases. Its ability to inhibit proteolytic enzymes can be exploited in the treatment of conditions associated with abnormal protease activity, such as inflammation, cancer, and neurodegenerative diseases.
Used in Diagnostic Applications:
Leupeptin Hydrochloride can be employed as a diagnostic aid in the detection and measurement of protease activity in various biological samples. Its specificity for different proteases allows for the accurate assessment of enzyme activity and can be used to monitor disease progression or the effectiveness of therapeutic interventions.

InChI:InChI=1/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H