24125-33-5Relevant articles and documents
Pilot-Scale Lipase-Catalyzed Regioselective Acylation of Ribavirin in Anhydrous Media in the Synthesis of a Novel Prodrug Intermediate
Tamarez, Maria,Morgan, Brian,Wong, George S. K.,Tong, Weidong,Bennett, Frank,Lovey, Raymond,McCormick, Jinping L.,Zaks, Aleksey
, p. 951 - 953 (2003)
The ester 4 was synthesized via Candida antarctica lipase-catalyzed acylation of ribavirin (3) with the oxime ester of L-Cbz-Ala (2) in anhydrous THF. The reaction was highly regioselective, resulting in the exclusive acylation of the 5′-hydroxyl. The pro