24245-55-4

Basic information

• Product Name: (1S,3S,4R)-3-(4-Chloro-phenylsulfanyl)-1-methyl-piperidine-4-carboxylic acid ethyl ester
• CAS NO: 24245-55-4
• Molecular Weight: 313.848
• Mol File: 24245-55-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1S,3S,4R)-3-(4-Chloro-phenylsulfanyl)-1-methyl-piperidine-4-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,3S,4R)-3-(4-Chloro-phenylsulfanyl)-1-methyl-piperidine-4-carboxylic acid ethyl ester(24245-55-4)
• EPA Substance Registry System: (1S,3S,4R)-3-(4-Chloro-phenylsulfanyl)-1-methyl-piperidine-4-carboxylic acid ethyl ester(24245-55-4)

Safety Data

• Hazardous Substances Data: 24245-55-4(Hazardous Substances Data)

Upstream product

• 40175-06-2 ethyl 1-methyl-1,2,5,6-tetrahydropyridine-4-carboxylate 
• 106-54-7 p-Chlorothiophenol 

Relevant articles and documents

Preparation and Stereochemistry of Methyl 3-(and 4)-p-Chlorothiophenoxy-1-methylpiperidine-4-(and 3)-carboxylates, and Cyclization to Benzothiopyranopyridinones

The title piperidines were prepared by (a) methanolysis of the corresponding nitriles and (b) addition of p-chlorothiophenol to the appropriate tetrahydropyridines.Three esters were obtained with stereochemistry assigned by nmr analysis: 2 , 5 , 6 .Compounds 2 and 6 cyclized in 70percent sulfuric acid.The product structures were established by X-ray crystallography and, suprisingly, both had trans-fused rings.Compound 5, however, did not cyclize but gave 4-(methylthio)chlorobenzene as the sole isolated product.