24271-94-1

Basic information

• Product Name: 1-Propanone, 1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)-
• CAS NO: 24271-94-1
• Molecular Formula: C15H14O3
• Molecular Weight: 242.274
• Mol File: 24271-94-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)-(24271-94-1)
• EPA Substance Registry System: 1-Propanone, 1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)-(24271-94-1)

Safety Data

• Hazardous Substances Data: 24271-94-1(Hazardous Substances Data)

Upstream product

• 3327-24-0 1-(2-hydroxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one 
• 1214-47-7 1-(2-hydroxyphenyl)-3-phenylprop-2-en-1-one 
• 3034-08-0 2-(4-methoxyphenyl)-2,3-dihydro-4H-chromen-4-one 
• 118-93-4 o-hydroxyacetophenone 
• 487-26-3 Flavanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 100-52-7 benzaldehyde 
• 123-08-0 4-hydroxy-benzaldehyde 
• 34000-31-2 2',4-dihydroxychalcone 
• 200411-98-9 3-(4-benzyloxyphenyl)-1-(2-hydroxylphenyl)-prop-2-en-1-one 

Downstream Products

• 201424-65-9 3-(4-hydroxybenzyl)-chroman-4-one 
• 6515-37-3 2-(4-hydroxyphenyl)chroman-4-one 
• 4143-63-9 4'-hydroxyflavone 
• 71809-05-7 1-(2-hydroxyphenyl)-3-(4-hydroxyphenyl)propane 

Relevant articles and documents

Stereoselective reduction of flavanones by marine-derived fungi

Biotransformation is an alternative with great potential to modify the structures of natural and synthetic flavonoids. Therefore, the bioreduction of synthetic halogenated flavanones employing marine-derived fungi was described, aiming the synthesis of flavan-4-ols 3a-g with high enantiomeric excesses (ee) of both cis- and trans-diastereoisomers (up to >99% ee). Ten strains were screened for reduction of flavanone 2a in liquid medium and in phosphate buffer solution. The most selective strains Cladosporium sp. CBMAI 1237 and Acremonium sp. CBMAI1676 were employed for reduction of flavanones 2a-g. The fungus Cladosporium sp. CBMAI 1237 presented yields of 72–87% with 0–64% ee cis and 0–30% ee trans with diastereoisomeric ratio (dr) from 52:48 to 64:36 (cis:trans). Whereas Acremonium sp. CBMAI 1676 resulted in 31% yield with 77–99% ee of the cis and 95–99% ee of the trans-diastereoisomers 3a-g with a dr from 54:46 to 96:4 (cis:trans). To our knowledge, this is the first report of the brominated flavon-4-ols 3e and 3f. The use of fungi, with emphasis for these marine-derived strains, is an interesting approach for enantioselective reduction of halogenated flavanones. Therefore, this strategy can be explored to obtain enantioenriched compounds with biological activities.

Synthesis, anticancer, structural, and computational docking studies of 3-benzylchroman-4-one derivatives

A series of 3-Benzylchroman-4-ones were synthesized and screened for anticancer activity by MTT assay. The compounds were evaluated against two cancerous cell lines BT549 (human breast carcinoma), HeLa (human cervical carcinoma), and one noncancerous cell

Total synthesis of 3′,3?-binaringenin and related biflavonoids

The synthesis of natural 3++,3?-binaringenin and four related biflavonoids was performed in good overall yield (15-35%) starting from readily available phloroglucinol and 4-hydroxy- or 4-methoxybenzaldehyde. Preliminary results indicate that some of these compounds have an interesting activity against S. aureus. Georg Thieme Verlag Stuttgart.