24302-12-3

Basic information

• Product Name: (E)-2-(Ethoxycarbonyl)-3-phenylprop-2-enoic acid
• Synonyms: (E)-2-(Ethoxycarbonyl)-3-phenylprop-2-enoic acid
• CAS NO: 24302-12-3
• Molecular Weight: 220.225
• Mol File: 24302-12-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (E)-2-(Ethoxycarbonyl)-3-phenylprop-2-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(Ethoxycarbonyl)-3-phenylprop-2-enoic acid(24302-12-3)
• EPA Substance Registry System: (E)-2-(Ethoxycarbonyl)-3-phenylprop-2-enoic acid(24302-12-3)

Safety Data

• Hazardous Substances Data: 24302-12-3(Hazardous Substances Data)

Upstream product

• 124-38-9 carbon dioxide 
• 5292-53-5 diethyl benzalmalonate 
• 100-52-7 benzaldehyde 
• 6148-64-7 ethyl potassium malonate 

Downstream Products

• 934619-02-0 (E)-3-phenyl-2-trityloxycarbamoylacrylic acid 
• 173221-15-3 E-ethyl tert-butylamidobenzalmalonate 
• 4192-77-2 ethyl cinnamate 

Relevant articles and documents

Copper-Catalyzed Carboxylation of C-F Bonds with CO2

An effective Cu-catalyzed selective formal carboxylation of C-F bonds with an atmospheric pressure of CO2 is reported. A variety of gem-difluoroalkenes, gem-difluorodienes, and α-trifluoro-methyl alkenes show high reactivity and selectivity for

Synthesis of polysubstituted 1,3-cyclohexadicnes from β-branched α,β-alkenals and monoesters of ylidenemalonic acids

3-Methyl- and 3-phenyl-2-butenal react with monoesters of alkylidene-, alkenylidene-, and arylmethylenemalonic acids in the presence of piperidine as the catalyst to give esters of 4,6-disubstituted 1,3-cyclohexadienecarboxylic acids in 23-96 % yields. Under the same conditions cyclohexylideneacetic aldehyde reacts with the monoesters of prenylidene- and benzylidenemalonic acid to afford mixtures of 1,8a-trans- and 1,8a-cis-isomers of 1-substituted alkyl 1,5,6,7,8,8a-hexahydronaphthalene-2-carboxylates, the ratios and configurations of which were determined by means of 1H NMR spectroscopy. In some cases the formation of cyclic dienes is impeded by the competing process of decarboxylation of acidic ylidenemalonates. The derivatives of 4,6-diphenyl-1,3-cyclohexadienecarboxylic acid were shown to be convenient precursors for the preparation of meta-terphenyls.

Enzyme-Catalyzed Hydrolyses of E/Z-Diastereotopic and E/Z-Diastereomeric Esters. Affect on Selectivity by Reaction Media

PLE-catalyzed hydrolyses of different types of E/Z-diastereotopic diesters and E/Z-diastereomeric monoesters have been studied.Arylidenepropanedioic diesters are specifically hydrolyzed to the Z-half esters, whereas the de values for dialkylated methylene propanedioic diesters range between 33 and 79percent (Z).D values for the hydrolyses of the 3-methyleneazetidin-2-ones in detergent-buffer systems depend on the size of the substituent in the α-position.Diastereoselectivity of these substrates is affected by addition of the cosolvents acetonitrile and methanol.