24318-00-1Relevant articles and documents
Synthesis of 14C-labeled 4-hydroxyindole as an intermediate for the preparation of (S)-2-14-12-13-(indol-2-[14C]-4-yloxy)-2-hydroxypropylaminol -2-methylpropyl]- phenoxylpyridine-5-carboxamide (LY368842-[indole-14C]) glyco
Czeskis, Boris A.,Clodfelter, Dean K.,Wheeler, William J.
, p. 1143 - 1152 (2002)
Synthesis of 4-hydroxyindole labeled with 14C at the 2-position was accomplished based on the vicarious nucleophilic substitution reaction of benzyl-protected 3-nitrophenol with p-chlorophenoxyacetonitrile-[1-14C]. This was followed
A inter-b-aminophenol preparation method
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Paragraph 0052-0054, (2019/07/01)
The invention belongs to organic synthesis and chemical raw material preparation technical field, and in particular relates to inter-b-aminophenol and intermediate preparation method, inter-b-aminophenol of the preparation method, comprises the steps of: (1) dinitrobenzene substituted benzyl alcohol generated by the reaction with 1 - benzyloxy - 3 - nitrophenyl; (2) 1 - benzyloxy - 3 - nitrobenzene with acetaldehyde in the foaming PH to acid substituted in the reaction solution, or 1 - benzyloxy - 3 - nitrobenzene with acetaldehyde to replace after the recovery of the solvent of the reaction solution dissolved in the dissolving of the re-dissolved solution in organic solvent, by reducing amination and catalytic debenzylation of hydrogenation generating inter-b-aminophenol. 1 - Benzyloxy - 3 - nitrophenyl without separation and purification, directly with the aldehyde and hydrogen reduction amination and debenzylation of hydrogenation reaction. The method is simple, mild condition, equipment strength requirement is low, not produce waste, environment friendly, easily available raw materials, high yield, is suitable for the large-scale generation.
[Cp?RhCl2]2-catalyzed alkyne hydroamination to 1,2-dihydroquinolines
Kumaran, Elumalai,Leong, Weng Kee
, p. 1779 - 1782 (2015/05/20)
[Cp?RhCl2]2 catalyzes the formation of 1,2-dihydroquinolines from the reaction of two terminal alkynes and an aniline. This reaction is believed to proceed via an alkyne hydroamination followed by an alkyne insertion.