24337-53-9

Basic information

• Product Name: cis-2-(1-hydroxy-1-methylethyl)cyclohexanol
• CAS NO: 24337-53-9
• Molecular Weight: 158.241
• Mol File: 24337-53-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: cis-2-(1-hydroxy-1-methylethyl)cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: cis-2-(1-hydroxy-1-methylethyl)cyclohexanol(24337-53-9)
• EPA Substance Registry System: cis-2-(1-hydroxy-1-methylethyl)cyclohexanol(24337-53-9)

Safety Data

• Hazardous Substances Data: 24337-53-9(Hazardous Substances Data)

Upstream product

• 286-20-4 cyclohexane-1,2-epoxide 
• 14032-04-3 trans-2-phenylthiocyclohexanol 
• 67-64-1 acetone 
• 917-64-6 methyl magnesium iodide 
• 2236-11-5 methyl 2-hydroxycyclohexanecarboxylate 
• 3304-23-2 2-(1'-hydroxy-1-methylethyl)cyclohexanone 
• 936-03-8 trans-2-carbomethoxycyclohexan-1-ol 
• 936-03-8 (+/-)-cis-2-hydroxy-cyclohexanecarboxylic acid methyl ester 

Downstream Products

• 25910-97-8 1-(1-hydroxy-1-methylethyl)cyclohexene 
• 89964-56-7 trans-2-(1-hydroxy-1-methylethyl)cyclohexyl p-toluenesulfonate 

Relevant articles and documents

Functionalized organolithium compounds of DTBB-catalyzed sulfur-lithium exchange

The successive reaction of β- or γ-hydroxy or amino phenyl thioethers (1,4) with butyllithium and an excess of lithium powder in the presence of a catalytic amount of DTBB in THF at - 78°C leads to the formation of the corresponding β- or γ-functionalized organolithium compounds 2 or 5, respectively, which by treatment with different electrophiles [D2O, t- BuCHO, PhCHO, Me2CO, (CH2)4CO, (CH2)5CO] at temperatures ranging between - 78°C and room temperature yields, after hydrolysis with water, the expected functionalized alcohols or amines 3 or 6, respectively, in a completely regioselective manner.