243982-41-4Relevant articles and documents
Practical and scalable synthesis of orthogonally protected-2-substituted chiral piperazines
Chamakuri, Srinivas,Santini, Conrad,Shah, Manuj M.,Yang, David C. H.,Young, Damian W.
, p. 8844 - 8849 (2020/11/23)
A synthetic route to orthogonally protected, enantiomerically pure 2-substituted piperazines is described. Starting from α-amino acids, within four steps chiral 2-substituted piperazines are obtained. The key transformation involves an aza-Michael additio
(R)-3,3,3-trifluoro-2-hydroxy-2-methyl- propionamides are orally active inhibitors of pyruvate dehydrogenase kinase [2]
Aicher, Thomas D.,Anderson, Robert C.,Bebernitz, Gregory R.,Coppola, Gary M.,Jewell, Charles F.,Knorr, Douglas C.,Liu, Charles,Sperbeck, Donald M.,Brand, Leonard J.,Strohschein, Robert J.,Gao, Jiaping,Vinluan, Christine C.,Shetty, Suraj S.,Dragland, Carol,Kaplan, Emma L.,DelGrande, Dominick,Islam, Amin,Liu, Xilin,Lozito, Robert J.,Maniara, Wieslawa M.,Walter, R. Erik,Mann, William R.
, p. 2741 - 2746 (2007/10/03)
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