2448-58-0Relevant articles and documents
Hydrogen bond surrogate stabilized water soluble 310-helix from a disordered pentapeptide containing coded α-amino acids
Pal, Sunit,Prabhakaran, Erode N.
, p. 2515 - 2519 (2018/05/28)
Replacing a hypothetical i + 3 → i peptide H-bond in a disordered pentapeptide, that lacks any helicogenic Cα-tetrasubstituted residues, with a propyl linker and carbamylating the N-terminal nitrogen constrains it in the elusive 310-helical structure with high helicity and stability under varying conditions of temperature and pH, confirmed by NMR and CD analyses.
Microwave-Assisted Synthesis of 2,2′-Azopyridine-Labeled Amines, Amino Acids, and Peptides
Avan, Ilker
, p. 365 - 378 (2016/01/28)
A microwave-assisted procedure for labeling amines, amino acids, and peptides with 2,2′-azopyridines (2,2′-AzPy) is described using the corresponding 2,2′-azopyridine-diacylbenzotriazoles. The efficiency of the procedure is proven by the generation of thr
Gabapentin hybrid peptides and bioconjugates
Lebedyeva, Iryna O.,Ostrov, David A.,Neubert, John,Steel, Peter J.,Patel, Kunal,Sileno, Sean M.,Goncalves, Kevin,Ibrahim, Mohamed A.,Alamry, Khalid A.,Katritzky, Alan R.
, p. 1479 - 1486 (2014/03/21)
Synthetic approaches to gabapentin bioconjugates that overcome the tendency of gabapentin to cyclize into its γ-lactam are studied. Gabapentin was converted by N-acylation at its N-terminus into di-, tri-, and tetrapeptides (L-Ala-Gbp, L-Val-Gbp, L-Ala-L-Phe-Gbp, Gly-L-Ala-β-Ala-Gbp). Carboxyl-activated Boc-protected gabapentin was used to N-, O-, and S-acylate small peptides and hormones to give conjugates that could also provide prodrugs containing conformationally constrained gabapentin units.
