24484-55-7

Basic information

• Product Name: 1-(3-Bromopropyl)-4-fluorobenzene
• Synonyms: 1-(3-Bromopropyl)-4-fluorobenzene
• CAS NO: 24484-55-7
• Molecular Formula: C₉H₁₀BrF
• Molecular Weight: 217.0781032
• Mol File: 24484-55-7.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 100 °C(Press: 1 Torr)
• Appearance: /
• Density: 1.390±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(3-Bromopropyl)-4-fluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-Bromopropyl)-4-fluorobenzene(24484-55-7)
• EPA Substance Registry System: 1-(3-Bromopropyl)-4-fluorobenzene(24484-55-7)

Safety Data

• Hazardous Substances Data: 24484-55-7(Hazardous Substances Data)

Usage

Description

1-(3-Bromopropyl)-4-fluorobenzene is a colorless liquid chemical compound with the molecular formula C9H9BrF. It is classified as a halogenated benzene, containing a fluorine atom and a bromine atom attached to the benzene ring, as well as a propyl group. 1-(3-Bromopropyl)-4-fluorobenzene is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals and is also known for its potential as a reagent in organic synthesis for the preparation of various functionalized aromatic compounds.

Uses

Used in Pharmaceutical Industry:
1-(3-Bromopropyl)-4-fluorobenzene is used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into the molecular structures of various drugs, enhancing their therapeutic properties and effectiveness.
Used in Agrochemical Industry:
1-(3-Bromopropyl)-4-fluorobenzene is used as an intermediate in the synthesis of agrochemicals for its potential to be incorporated into the molecular structures of pesticides and other agricultural chemicals, improving their efficacy in protecting crops and controlling pests.
Used in Organic Synthesis:
1-(3-Bromopropyl)-4-fluorobenzene is used as a reagent in organic synthesis for the preparation of various functionalized aromatic compounds, contributing to the development of new chemical entities with specific applications in different industries.

Upstream product

• 702-15-8 3-(4-fluorophenyl)propan-1-ol 
• 109-64-8 1,3-dibromo-propane 
• 352-13-6 4-flourophenylmagnesium bromide 
• 7116-38-3 ethyl 3-(4-fluorophenyl)propanoate 
• 459-32-5 (E)-4-fluorocinnamic acid 
• 136265-10-6 ethyl 4-fluorocinnamate 
• 96426-60-7 methyl (2E)-3-(4-fluorophenyl)-2-propenoate 
• 124980-95-6 (E)-3-(4-fluorophenyl)-2-propen-1-ol 
• 459-31-4 3-(4-fluorophenyl)propanoic acid 
• 459-46-1 4-Fluorobenzyl bromide 
• 59223-74-4 1,3-diethyl 2-[(4-fluorophenyl)methyl]propanedioate 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 637-59-2 1-Bromo-3-phenylpropane 
• 332-42-3 (2-bromoethyl)-4-fluorobenzene 

Downstream Products

• 57860-53-4 1-(3,5-Dimethoxy-phenyl)-5-(4-fluoro-phenyl)-2-methyl-pentan-1-one 
• 52763-25-4 2-(3,5-dimethoxyphenyl)-5-(4-fluorophenyl)-pentane 
• 59873-10-8 2-[3-(4-Fluoro-phenyl)-propoxy]-4-hydroxy-phenanthrene-3-carboxylic acid ethyl ester 
• 59873-12-0 2,4-Bis-[3-(4-fluoro-phenyl)-propoxy]-phenanthrene-3-carboxylic acid ethyl ester 
• 59873-23-3 1-[3-(4-Fluoro-phenyl)-propyl]-2,4-dihydroxy-phenanthrene-3-carboxylic acid ethyl ester 
• 59873-11-9 4-Acetoxy-2-[3-(4-fluoro-phenyl)-propoxy]-phenanthrene-3-carboxylic acid ethyl ester 
• 59873-17-5 2-[3-(4-Fluoro-phenyl)-propoxy]-phenanthren-4-ol 
• 59873-18-6 4-[3-(4-Fluoro-phenyl)-propoxy]-phenanthren-2-ol 
• 59873-20-0 Acetic acid 2-[3-(4-fluoro-phenyl)-propoxy]-phenanthren-4-yl ester 
• 86373-37-7 4-[3-(4-Fluoro-phenyl)-propylamino]-benzoic acid ethyl ester 
• 147223-87-8 1-benzyl-5-[4-(4-fluorophenyl)-1-hydroxybutyl]-1H-imidazole 
• 872414-39-6 2-acetylamino-2-[3-(4-fluoro-phenyl)-propyl]-malonic acid diethyl ester 
• 872414-42-1 (R)-2-Acetylamino-5-(4-fluoro-phenyl)-pentanoic acid 
• 616882-20-3 2-(tert-butoxycarbonylamino)-5-(4-fluorophenyl)-D-pentanoic acid 

Relevant articles and documents

B(C6F5)3-Catalyzed Diastereoselective Formal (4 + 1)-Cycloaddition of Vinylcyclopropanes and Et2SiH2

A formal (4 + 1)-cycloaddition of vinylcyclopropanes and Et2SiH2 to afford 3,4-disubstituted silolanes is reported. The reaction sequence commences with the known B(C6F5)3-catalyzed alkene hydrosilylation with dihydrosilanes. Cleavage of the remaining Si-H bond in the hydrosilylation product assisted by B(C6F5)3 leads to formation of a cyclopropane-stabilized silylium ion. The activated cyclopropane ring is then opened by the in situ-generated borohydride accompanied by ring closure to the silolane. The diastereoselectivity is rationalized by a mechanistic model.

Anodic benzylic C(sp3)-H amination: Unified access to pyrrolidines and piperidines

An electrochemical aliphatic C-H amination strategy was developed to access the important heterocyclic motifs of pyrrolidines and piperidines within a uniform reaction protocol. The mechanism of this unprecedented C-H amination strategy involves anodic C-H activation to generate a benzylic cation, which is efficiently trapped by a nitrogen nucleophile. The applicability of the process is demonstrated for 40 examples comprising both 5- and 6-membered ring formations.

DIRECT PALLADIUM-CATALYZED AROMATIC FLUORINATION

Provided herein are palladium complexes comprising a ligand of Formula (Α') and a ligand of Formula (B), wherein R1-R18 are as defined herein. The palladium complexes are useful in methods of fluorinating aryl and heteroaryl substrates. Further provided are compositions and kits comprising the palladium complexes.