24601-74-9 Usage
Description
(S)-4-ISOPROPYLOXAZOLIDINE-2,5-DIONE is an organic compound with a unique structure that features a five-membered azolidine ring and a 2,5-dione group. It is characterized by its white solid appearance and is known for its potential applications in various industries due to its chemical properties.
Uses
Used in Organic Synthesis:
(S)-4-ISOPROPYLOXAZOLIDINE-2,5-DIONE is used as a synthetic building block for the creation of more complex organic molecules. Its unique structure allows it to be a valuable component in the synthesis of various compounds, particularly those with pharmaceutical or chemical applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (S)-4-ISOPROPYLOXAZOLIDINE-2,5-DIONE is used as an intermediate in the development of new drugs. Its specific structural features make it a promising candidate for the design and synthesis of novel therapeutic agents.
Used in Chemical Research:
(S)-4-ISOPROPYLOXAZOLIDINE-2,5-DIONE is also utilized in chemical research as a model compound to study various reaction mechanisms and to understand the properties of similar organic compounds. This helps in the advancement of chemical knowledge and the development of new synthetic methods.
Used in Material Science:
The compound may also find applications in material science, where its unique structural features could be exploited to create new materials with specific properties, such as improved stability or reactivity.
Preparation
To a stirred suspension of l-valine (46.8 g, 0.4 mol) in dry THF (400 mL) was slowly added a solution of phosgene (0.8 mol)in toluene (stock solution ca. 5 m). In the closed vessel (Author’s remark: It is better to use a reflux condenser cooled to at least -15 ℃ or a dry-ice reflux condenser under ambient pressure), the mixture was stirred at 45 ℃ for 7 h in order to obtain a clear solution. The solvent was then evaporated in vacuo at room temperature. The residue was redissolved in dry THF and this solution was concentrated to dryness. The crystalline residue was dried over CaCl2 in vacuo; yield 57.0 g (quantitative).
Check Digit Verification of cas no
The CAS Registry Mumber 24601-74-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,6,0 and 1 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 24601-74:
(7*2)+(6*4)+(5*6)+(4*0)+(3*1)+(2*7)+(1*4)=89
89 % 10 = 9
So 24601-74-9 is a valid CAS Registry Number.
InChI:InChI=1/C6H9NO3/c1-3(2)4-5(8)10-6(9)7-4/h3-4H,1-2H3,(H,7,9)/t4-/m0/s1
24601-74-9Relevant articles and documents
Stereospecific hydrogenations. IV. Palladium-on-poly-S-valine and palladium-on-poly-S-leucine.
Beamer,Belding,Fickling
, p. 1419 - 1421 (1969)
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ANTIMICROBIAL COMPOSITION COMBINATIONS COMPRISING STAR SHAPED PEPTIDE POLYMERS
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Page/Page column 66, (2018/05/24)
This invention relates to compositions including antibacterial compounds. The invention also relates to the use of the compositions in methods of treating bacterial infections. In one aspect the present invention also provides a method of increasing the susceptibility of bacteria to the anti-bacterial activity of a compound, the method comprising contacting the bacteria with a star shaped peptide polymer of the invention, thereby increasing the susceptibility of the bacteria to the anti-bacterial activity of the compound. Preferably, the method further includes the step of contacting the bacteria with the compound for which the bacteria have increased susceptibility to. The invention is further relates to the combination of a star shaped peptide polymer and an anti- bacterial compound that restore the sensitivity of antibiotic resistant bacteria to antibiotics that are otherwise ineffective when administered alone.
A new simple and quantitative synthesis of α-aminoacid-N-carboxyanhydrides (oxazolidines-2,5-dione)
Collet, Helene,Bied, Catherine,Mion, Louis,Taillades, Jacques,Commeyras, Auguste
, p. 9043 - 9046 (2007/10/03)
Nitrosation of chiral N-carbamoylaminoacids with a mixture of NO and O2 gives, with the same configuration and in quantitative yield the corresponding α-aminoacid-N-carboxyanhydrides (NCA), well known precursors of peptides. The by products of this reaction are N2 and H2O. Copyright (C) 1996 Elsevier Science Ltd.
ENANTIOMERIC QUANTIFICATIONS OF AMINO ACIDS THROUGH THEIR Nα-ACYL AMIDES BY GAS CHROMATOGRAPHY.
Hosten, N.,Anteunis, M. J. O.
, p. 45 - 47 (2007/10/02)
Apparent separation of 1.1 or higher on Chiralsil Val III can be obtained for Nα-acyl N-alkyl aminoacid amides allowing the use of short capillary gas chromatographic columns.A clean derivatization protocol without racemization is described, proceding through the NCA derivatives that are prepared from "in situ" silylated amino acids with trimethylsilyl cyanide.
