247134-05-0Relevant articles and documents
Regioselectivity of the Conjugate Addition of Amines to Dissymmetrical Pull-Pull Alkenes
Maddaluno, Jacques,Rulev, Alexander Yu.,Semenov, Valentin A.,Ushakov, Igor A.,Vashchenko, Alexander V.,Zubkov, Ilya N.
, p. 3278 - 3288 (2021)
The regioselectivity of the conjugate nucleophilic addition of amines to vicinal di-acceptor-substituted alkenes has been studied. A set of results obtained with standard primary and secondary amines gives some clues on the relative acceptor character of classical electron-withdrawing groups (EWG). We have shown in addition that computed inverse local nucleophilicity index can be used to predict the regioselectivity of the nucleophilic attack.
Barbier conditions for reformatsky and alkylation reactions on trifluoromethyl aldimines
Dos Santos, Mickael,Crousse, Benoit,Bonnet-Delpon, Danièle
, p. 399 - 401 (2008/09/16)
β-Trifluoromethyl β-amino acids and α-trifluoromethyl α-alkyl amines can be easily prepared under Barbier conditions from trifluoromethyl aldimines in moderate to good yields. β-Trifluoromethyl β-amino acids were obtained in good enantioselectivity from t