247186-50-1

Basic information

• Product Name: TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE
• Synonyms: TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE;tert-Butyl 3-benzyloxy-4-bromobenzoate 98%;tert-Butyl3-benzyloxy-4-bromobenzoate98%
• CAS NO: 247186-50-1
• Molecular Formula: C₁₈H₁₉BrO₃
• Molecular Weight: 363.24566
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 247186-50-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 443.3 °C at 760 mmHg
• Flash Point: 221.9 °C
• Appearance: /
• Density: 1.307 g/cm³
• Vapor Pressure: 4.7E-08mmHg at 25°C
• Refractive Index: 1.567
• Storage Temp.: 2-8°C
• CAS DataBase Reference: TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE(247186-50-1)
• EPA Substance Registry System: TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE(247186-50-1)

Safety Data

• Hazardous Substances Data: 247186-50-1(Hazardous Substances Data)

Usage

General Description

TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE is a synthetic compound with a complex chemical structure. It is a derivative of benzoic acid and contains a tert-butyl group, a benzyl ether group, and a bromine atom attached to a benzene ring. TERT-BUTYL 3-BENZYLOXY-4-BROMOBENZOATE is commonly used in organic synthesis and pharmaceutical research as a reagent or intermediate for the production of various chemical compounds. Its specific chemical properties and potential applications are of interest to researchers in the fields of medicinal chemistry and drug development.

InChI:InChI=1/C18H19BrO3/c1-18(2,3)22-17(20)14-9-10-15(19)16(11-14)21-12-13-7-5-4-6-8-13/h4-11H,12H2,1-3H3

Upstream product

• 17054-27-2 4-bromo-3-benzyloxybenzoic acid 
• 75-65-0 tert-butyl alcohol 
• 14348-38-0 4-bromo-3-hydroxybenzoic acid 
• 124318-23-6 3-Benzyloxy-4-brombenzoesaeure-benzylester 
• 100-39-0 benzyl bromide 

Downstream Products

• 440105-05-5 4-tert-butyloxycarbonyl-2-benzyloxybenzoic acid 
• 440105-07-7 3-benzyloxy-4-[6-benzyloxy-2-(1,3-dioxan-2-yl)benzoyl]benzoic acid 
• 440105-06-6 1,1-dimethylethyl 3-benzyloxy-4-[6-benzyloxy-2-(1,3-dioxan-2-yl)benzoyl]benzoate 

Relevant articles and documents

Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits

A series of analogues of the protein kinase C (PKC) inhibitory natural product balanol which bear modified benzophenone subunits are described. The analogues were designed with the goal of uncovering structure -activity features that could be used in the development of PKC inhibitors with a reduced polar character compared to balanol itself. The results of these studies suggest that most of the benzophenone features found in the natural product are important for obtaining potent PKC inhibitory compounds. However, several modifications were found to lead to selective inhibitors of the related enzyme protein kinase A (PKA), and several specific modifications to the polar structural elements of the benzophenone were found to provide potent PKC inhibitors. In particular, it was found that replacement of the benzophenone carboxylate with bioisosteric equivalents could lead to potent analogues. Further, a tolerance for lipophilic substituents on the terminal benzophenone ring was uncovered. These results are discussed in light of recently available structural information for PKA.