24719-72-0

Basic information

• Product Name: Aspirin-acyl--D-glucuronide
• Synonyms: 1-[2-(Acetyloxy)benzoate] -D-Glucopyranuronic Acid;1-Salicylate Monoacetate -D-Glucopyranuronic Acid;Acetylsalicylic Acid Acyl--D-glucuronide;Aspirin-acyl--D-glucuronide;2-Acetylsalicylic acid acyl-b-D-glucuronide;2-Acetylsalicylic acid acyl-β-D-glucuronide;Acetylsalicylic acid-acyl-beta-D-glucuronide, ASA-acyl-beta-D-glucuronide, 2-Acetoxybenzoic acid-acyl-beta-D-glucuronide;Aspirin-acyl-beta-D-glucuronide min. 95%
• CAS NO: 24719-72-0
• Molecular Formula: C15H16O10
• Molecular Weight: 356.28
• Product Categories: Glucuronides;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 24719-72-0.mol
• Article Data: 0

Chemical Properties

• Melting Point: 145-147°C
• Boiling Point: 592.532 °C at 760 mmHg
• Flash Point: 219.46 °C
• Appearance: /
• Density: 1.615 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.625
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• PKA: 2.66±0.70(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: Aspirin-acyl--D-glucuronide(CAS DataBase Reference)
• NIST Chemistry Reference: Aspirin-acyl--D-glucuronide(24719-72-0)
• EPA Substance Registry System: Aspirin-acyl--D-glucuronide(24719-72-0)

Safety Data

• Hazardous Substances Data: 24719-72-0(Hazardous Substances Data)

Usage

Description

Aspirin-acyl--D-glucuronide is a significant metabolite of Salicylic acid (SA) and Aspirin, characterized by its off-white solid appearance. It is a product of the metabolic process involving the conversion of Aspirin into a more water-soluble form, which facilitates its excretion from the body.

Uses

Used in Pharmaceutical Industry:
Aspirin-acyl--D-glucuronide is used as a metabolite in the pharmaceutical industry for its role in the metabolism and excretion of Aspirin. This metabolite is crucial for understanding the pharmacokinetics and pharmacodynamics of Aspirin, which is widely used for its analgesic, anti-inflammatory, and antipyretic properties.
Used in Research and Development:
In the field of research and development, Aspirin-acyl--D-glucuronide serves as a valuable compound for studying the metabolic pathways of Aspirin and its effects on the human body. This knowledge can be applied to improve drug design, optimize dosages, and minimize side effects associated with Aspirin use.
Used in Toxicology Studies:
Aspirin-acyl--D-glucuronide is also used in toxicology studies to evaluate the safety and potential adverse effects of Aspirin. By understanding the metabolic conversion of Aspirin to its glucuronide form, researchers can better assess the risks and benefits of Aspirin consumption, particularly in cases of overdose or long-term use.
Used in Drug Metabolism and Pharmacogenetics:
In the study of drug metabolism and pharmacogenetics, Aspirin-acyl--D-glucuronide is utilized to investigate the genetic factors that influence an individual's ability to metabolize Aspirin. This information can help identify patients who may be at a higher risk for adverse reactions or those who may require adjusted dosages for optimal therapeutic effects.

InChI:InChI=1/C15H16O10/c1-6(16)23-8-5-3-2-4-7(8)14(22)25-15-11(19)9(17)10(18)12(24-15)13(20)21/h2-5,9-12,15,17-19H,1H3,(H,20,21)/t9-,10-,11-,12?,15-/m0/s1