24719-82-2 Usage
Description
N6-[((1S,2R)-1-CARBOXY-2-HYDROXYBUTYLAMINO)CARBONYL]ADENOSINE SODIUM SALT, also known as N6-(N-Threonylcarbonyl)adenosine, is an essential modified nucleoside found in tRNA responsible for ANN codons in all three domains of life. It is characterized by an N-(adenosin-N6-ylcarbonyl)threonine with L-configuration in the threonine portion. N6-[((1S,2R)-1-CARBOXY-2-HYDROXYBUTYLAMINO)CARBONYL]ADENOSINE SODIUM SALT serves as a biological marker in neoplastic diseases, making it significant for research and potential therapeutic applications.
Uses
Used in Biomedical Research:
N6-[((1S,2R)-1-CARBOXY-2-HYDROXYBUTYLAMINO)CARBONYL]ADENOSINE SODIUM SALT is used as a biological marker for neoplastic diseases, aiding in the identification and understanding of various types of cancer. Its presence in tRNA and association with ANN codons make it a valuable tool for studying the molecular mechanisms underlying cancer development and progression.
Used in Pharmaceutical Development:
In the pharmaceutical industry, N6-[((1S,2R)-1-CARBOXY-2-HYDROXYBUTYLAMINO)CARBONYL]ADENOSINE SODIUM SALT may be utilized as a starting point for the development of novel therapeutic agents targeting neoplastic diseases. Its unique structure and function in tRNA could potentially be leveraged to create drugs that interfere with cancer-related processes, offering new treatment options for patients.
Used in Diagnostic Applications:
N6-[((1S,2R)-1-CARBOXY-2-HYDROXYBUTYLAMINO)CARBONYL]ADENOSINE SODIUM SALT can be employed in the development of diagnostic tools and tests for neoplastic diseases. As a biological marker, it may help in the early detection of cancer, enabling more timely and effective treatment strategies.
Used in Drug Delivery Systems:
Similar to gallotannin, N6-[((1S,2R)-1-CARBOXY-2-HYDROXYBUTYLAMINO)CARBONYL]ADENOSINE SODIUM SALT could be incorporated into drug delivery systems to enhance its therapeutic potential. By using various organic and metallic nanoparticles as carriers, the compound's delivery, bioavailability, and overall effectiveness against neoplastic diseases could be improved.
Check Digit Verification of cas no
The CAS Registry Mumber 24719-82-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,7,1 and 9 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 24719-82:
(7*2)+(6*4)+(5*7)+(4*1)+(3*9)+(2*8)+(1*2)=122
122 % 10 = 2
So 24719-82-2 is a valid CAS Registry Number.
InChI:InChI=1/C15H20N6O8/c1-5(23)7(14(26)27)19-15(28)20-11-8-12(17-3-16-11)21(4-18-8)13-10(25)9(24)6(2-22)29-13/h3-7,9-10,13,22-25H,2H2,1H3,(H,26,27)(H2,16,17,19,20,28)/t5-,6-,7+,9-,10-,13-/m1/s1
24719-82-2Relevant articles and documents
Efficient access to 3′-: O -phosphoramidite derivatives of tRNA related N 6-threonylcarbamoyladenosine (t6A) and 2-methylthio- N 6-threonylcarbamoyladenosine (ms2t6A)
Debiec, Katarzyna,Sochacka, Elzbieta
, p. 1992 - 1999 (2021)
An efficient method of ureido linkage formation during epimerization-free one-pot synthesis of protected hypermodified N6-threonylcarbamoyladenosine (t6A) and its 2-SMe analog (ms2t6A) was developed. The method is based on a Tf2O-mediated direct conversion of the N-Boc-protecting group of N-Boc-threonine into the isocyanate derivative, followed by reaction with the N6exo-amine function of the sugar protected nucleoside (yield 86-94%). Starting from 2′,3′,5′-tri-O-acetyl protected adenosine or 2-methylthioadenosine, the corresponding 3′-O-phosphoramidite monomers were obtained in 48% and 42% overall yield (5 step synthesis). In an analogous synthesis, using the 2′-O-(tert-butyldimethylsilyl)-3′,5′-O-(di-tert-butylsilylene) protection system at the adenosine ribose moiety, the t6A-phosphoramidite monomer was obtained in a less laborious manner and in a remarkably better yield of 74%.
Noncanonical RNA Nucleosides as Molecular Fossils of an Early Earth—Generation by Prebiotic Methylations and Carbamoylations
Schneider, Christina,Becker, Sidney,Okamura, Hidenori,Crisp, Antony,Amatov, Tynchtyk,Stadlmeier, Michael,Carell, Thomas
supporting information, p. 5943 - 5946 (2018/04/30)
The RNA-world hypothesis assumes that life on Earth started with small RNA molecules that catalyzed their own formation. Vital to this hypothesis is the need for prebiotic routes towards RNA. Contemporary RNA, however, is not only constructed from the four canonical nucleobases (A, C, G, and U), it also contains many chemically modified (noncanonical) bases. A still open question is whether these noncanonical bases were formed in parallel to the canonical bases (chemical origin) or later, when life demanded higher functional diversity (biological origin). Here we show that isocyanates in combination with sodium nitrite establish methylating and carbamoylating reactivity compatible with early Earth conditions. These reactions lead to the formation of methylated and amino acid modified nucleosides that are still extant. Our data provide a plausible scenario for the chemical origin of certain noncanonical bases, which suggests that they are fossils of an early Earth.
