24768-82-9

Basic information

• Product Name: 4-IODO-3,5-DIPHENYLISOXAZOLE
• Synonyms: 4-IODO-3,5-DIPHENYLISOXAZOLE
• CAS NO: 24768-82-9
• Molecular Formula: C₁₅H₁₀INO
• Molecular Weight: 347.15
• Mol File: 24768-82-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 171-172 °C
• Boiling Point: 453.2 °C at 760 mmHg
• Flash Point: 227.9 °C
• Appearance: /
• Density: 1.591 g/cm³
• PKA: -4.88±0.10(Predicted)
• CAS DataBase Reference: 4-IODO-3,5-DIPHENYLISOXAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODO-3,5-DIPHENYLISOXAZOLE(24768-82-9)
• EPA Substance Registry System: 4-IODO-3,5-DIPHENYLISOXAZOLE(24768-82-9)

Safety Data

• Hazardous Substances Data: 24768-82-9(Hazardous Substances Data)

Usage

General Description

4-Iodo-3,5-diphenylisoxazole is a chemical compound with the molecular formula C18H13INO, and it is classified as an isoxazole derivative. It is commonly used in organic synthesis and pharmaceutical research as a building block for the development of new compounds with potential biological activity. 4-IODO-3,5-DIPHENYLISOXAZOLE exhibits interesting properties due to the presence of an iodo substituent, including reactivity in cross-coupling reactions and potential biological effects. Its unique structure makes it valuable in the production of various pharmaceuticals, agrochemicals, and materials for research and industrial applications. Overall, 4-Iodo-3,5-diphenylisoxazole is a versatile chemical compound with significant potential for further study and application in the field of chemistry and pharmacology.

Upstream product

• 2039-49-8 3,5-diphehylisoxazole 
• 870127-38-1 (Z)-1,3-diphenylprop-2-yn-1-one O-methyl oxime 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 98-88-4 benzoyl chloride 
• 536-74-3 phenylacetylene 
• 29881-14-9 1,2-diphenyl-cyclopropane 

Downstream Products

• 2039-49-8 3,5-diphehylisoxazole 
• 2289-55-6 methyl [3,5-diphenylisoxazol-4-yl]carboxylate 
• 10557-79-6 4-chloro-3,5-diphenylisoxazole 
• 10557-78-5 3,5-diphenyl-4-bromoisoxazole 
• 1374745-80-8 3,5-diphenyl-4-(trifluoromethanesulfonyl)isoxazole 

Relevant articles and documents

R4NHal/NOHSO4: A Usable System for Halogenation of Isoxazoles, Pyrazoles, and beyond

A new convenient and versatile halogenating system (R4NHal/NOHSO4), giving straightforward and general access to halogenated 3,5-diaryl- and alkylarylisoxazoles, pyrazoles and electron-rich benzenes from the corresponding scaffolds, is suggested. The method provides excellent regioselectivity, scalability to the gram scale, and a broad scope for both aromatics and halogens. A three-step, one-pot reaction protocol was developed, and a series of 3,5-diaryl-4-haloisoxazoles has been efficiently synthesized from 1,2-diarylcyclopropanes under suggested nitrosating-halogenating conditions.

Isomerizable (: E / Z)-alkynyl- O -methyl oximes employing TMSCl-NCS in chlorinative cyclization for the direct synthesis of 4-chloroisoxazoles

For the first time, 4-chloroisoxazoles are directly synthesized in moderate to excellent yields from (E/Z)-alkynyl-O-methyl oximes via chlorinative cyclization. The synthesis employs the combination of N-chlorosuccinimide (NCS) and chlorotrimethylsilane (

Synthesis of isoxazoles via electrophilic cyclization

(Chemical Equation Presented) A variety of 3,5-disubstituted 4-halo(seleno)isoxazoles are readily prepared in good to excellent yields under mild reaction conditions by the reaction of 2-alkyn-1-one O-methyl oximes with ICI, I2, Br2,