24768-98-7

Basic information

• Product Name: N,N-bis(trideuteriomethyl)benzamide
• Synonyms: N,N-bis(trideuteriomethyl)benzamide
• CAS NO: 24768-98-7
• Molecular Weight: 155.145
• Mol File: 24768-98-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N,N-bis(trideuteriomethyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(trideuteriomethyl)benzamide(24768-98-7)
• EPA Substance Registry System: N,N-bis(trideuteriomethyl)benzamide(24768-98-7)

Safety Data

• Hazardous Substances Data: 24768-98-7(Hazardous Substances Data)

Upstream product

• 53170-19-7 d6-dimethylamine hydrochloride 
• 98-88-4 benzoyl chloride 
• 4472-41-7 d₇-N,N-dimethylformamide 

Downstream Products

• 144601-75-2 N-trideuteriomethyl-benzamide 
• 143958-59-2 N,N-dimethylbenzylamine-d8 

Relevant articles and documents

Identification of unexpected unlabeled N,N-dimethylamide formation in the synthesis of deuterated fragment of ribociclib by a HATU-mediated coupling reaction

Starting from N,N-dimethylamine and D2O, deuterated fragment of ribociclib was synthesized for use as a mass spectroscopy internal standard. Furthermore, systematic studies on D0 (unlabeled material) formation during the amidation reaction were performed, leading to the identification of a coupling reagent, HATU (O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate), as main cause. Finally, an alternative route was designed using EDCI/HOBT as coupling reagents to produce the desired deuterated compound without D0 residue.

Electrochemical Models for Cytochrome P-450. N-Demethylation of Tertiary Amides by Anodic Oxidation

Anodic oxidation of N,N-dimethylamides in acetonitrile/water (95:5) containing NaClO4 gives the corresponding N-methylamides in high yields.N-Methyl-N-(hydroxymethyl)benzamide was isolated as an intermediate in the electrochemical N-demethylation of N,N-d