248-85-1Relevant articles and documents
A versatile synthesis of annulated carbazole analogs involving a domino reaction of bromomethylindoles with arenes/heteroarenes
Dhayalan, Vasudevan,Clement, J. Arul,Jagan, Radhakrishnan,Mohanakrishnan, Arasambattu K.
experimental part, p. 531 - 546 (2009/09/06)
A ZnBr2-mediated arylation of aryl/heteroaryl methyl bromides with arenes at 80°C led to the formation of arylated products, which underwent subsequent 1,5-sigmatropic rearrangement followed by electrocyclization and aromatiza tion with loss of a diethylmalonate unit to afford the corresponding annulated products.
Thiophene analogues of carcinogenic polycyclic hydrocarbons. Elbs pyrolysis of various aroylmethylbenzo[b]thiophenes
Croisy,Mispelter,Lhoste,et al.
, p. 353 - 359 (2007/10/02)
The synthesis of two benzonaphthothiophenes and of four benzophenanthrothiophenes through Elbs cyclodehydration of ortho-methylated aroylbenzo[b]thiophenes is described. The occurrence of a rearrangement of the thiophene ring in the course of the cyclization is discussed as well as the influence of the temperature on a concurrent cyclodehydration process. Several of these poly-condensed thiophenes were found to be carcinogenic in mice.