24869-99-6 Usage
Description
Androstane-3,17-diol 17-sulfate, also known as 5α-androstan-3α,17β-diol 17-sulfate, is a chemical compound belonging to the androstane sulfate class. It is characterized by the presence of a sulfo group replacing the hydroxy hydrogen at position 17. androstane-3,17-diol 17-sulfate has potential applications in various fields due to its unique chemical structure and properties.
Uses
Used in Pharmaceutical Industry:
Androstane-3,17-diol 17-sulfate is used as an intermediate in the synthesis of various steroidal drugs for the treatment of hormonal imbalances and other related conditions. Its unique structure allows for the development of targeted therapies with minimal side effects.
Used in Research and Development:
In the field of research, androstane-3,17-diol 17-sulfate serves as a valuable compound for studying the structure-activity relationships of steroidal compounds. It can be used to investigate the effects of structural modifications on biological activity, leading to the discovery of novel therapeutic agents.
Used in Analytical Chemistry:
Androstane-3,17-diol 17-sulfate can be employed as a reference compound in the development and validation of analytical methods for the determination of steroidal compounds in various matrices, such as biological samples, pharmaceutical formulations, and environmental samples.
Used in Drug Delivery Systems:
Similar to gallotannin, androstane-3,17-diol 17-sulfate can be incorporated into drug delivery systems to improve its bioavailability and therapeutic efficacy. By utilizing nanoparticles or other carriers, the compound can be delivered more effectively to target tissues, enhancing its potential applications in medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 24869-99-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,8,6 and 9 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 24869-99:
(7*2)+(6*4)+(5*8)+(4*6)+(3*9)+(2*9)+(1*9)=156
156 % 10 = 6
So 24869-99-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H32O5S/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(24-25(21,22)23)19(15,2)10-8-16(14)18/h12-17,20H,3-11H2,1-2H3,(H,21,22,23)/t12?,13?,14-,15-,16-,17?,18-,19-/m0/s1
24869-99-6Relevant articles and documents
Liquid chromatography-mass spectrometry (LC-MS) of steroid hormone metabolites and its applications
Penning, Trevor M.,Lee, Seon-Hwa,Jin, Yi,Gutierrez, Alejandro,Blair, Ian A.
experimental part, p. 546 - 555 (2011/12/02)
Advances in liquid chromatography-mass spectrometry (LC-MS) can be used to measure steroid hormone metabolites in vitro and in vivo. We find that LC-electrospray ionization (ESI)-MS using a LCQ ion trap mass spectrometer in the negative ion mode can be used to monitor the product profile that results from 5α-dihydrotestosterone (DHT)-17β-glucuronide, DHT-17β-sulfate, and tibolone-17β-sulfate reduction catalyzed by human members of the aldo-keto reductase (AKR) 1C subfamily and assign kinetic constants to these reactions. We also developed a stable isotope dilution LC-electron capture atmospheric pressure chemical ionization (ECAPCI)-MS method for the quantitative analysis of estrone (E1) and its metabolites as pentafluorobenzyl (PFB) derivatives in human plasma in the attomole range. The limit of detection for E1-PFB was 740. attomole on column. Separations can be performed using normal-phase LC because ionization takes place in the gas phase rather than in solution. This permits efficient separation of the regioisomeric 2- and 4-methoxy-E1. The method was validated for the simultaneous analysis of plasma E2 and its metabolites: 2-methoxy-E2, 4-methoxy-E2, 16α-hydroxy-E2, estrone (E1), 2-methoxy-E1, 4-methoxy-EI, and 16α-hydroxy-E1 from 5. pg/mL to 2000. pg/mL. Our LC-MS methods have sufficient sensitivity to detect steroid hormone levels in prostate and breast tumors and should aid their molecular diagnosis and treatment.
