2491-20-5

Basic information

• Product Name: L-Alanine methyl ester hydrochloride
• Synonyms: L-ALANINE METHYL ESTER HYDROCHLORIDE;METHYL L-ALANINATE HYDROCHLORIDE;H-L-ALA-OME HCL;H-ALA-OME HCL;H-ALA-OME HYDROCHLORIDE;(S)-2-AMINOPROPIONIC ACID METHYL ESTER HYDROCHLORIDE;A-Ala-OMe·HCl ;L-ALANINE METHYL ESTER HYDROCHLORIDE, 99 %
• CAS NO: 2491-20-5
• Molecular Formula: C₄H₁₀NO₂*Cl
• Molecular Weight: 139.58
• EINECS: 219-652-4
• Product Categories: Amino Acids Derivatives;AMINOACIDS DERIVATIVES;Amino Acids;Alanine [Ala, A];Amino Acids and Derivatives;Amino Acid Methyl Esters;Amino Acids (C-Protected);Biochemistry;Amino hydrochloride;Alanine;Amino Acid Derivatives;Peptide Synthesis;amino acid;amino;Piperazines ,Oxazolines/Oxazolidines
• Mol File: 2491-20-5.mol
• Article Data: 130

Chemical Properties

• Melting Point: 109-111 °C(lit.)
• Boiling Point: 101.5 °C at 760 mmHg
• Appearance: White to off-white/Powder
• Vapor Pressure: 35mmHg at 25°C
• Refractive Index: 6.5 ° (C=2, MeOH)
• Storage Temp.: −20°C
• Solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
• Water Solubility: Soluble in Water (100 mg/ml).
• Sensitive: Hygroscopic
• BRN: 3594033
• CAS DataBase Reference: L-Alanine methyl ester hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanine methyl ester hydrochloride(2491-20-5)
• EPA Substance Registry System: L-Alanine methyl ester hydrochloride(2491-20-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: 3
• Hazardous Substances Data: 2491-20-5(Hazardous Substances Data)

Usage

Description

L-Alanine methyl ester hydrochloride is a white crystalline powder that is a derivative of the naturally occurring amino acid L-Alanine. It is characterized by the presence of a methyl ester group attached to the alpha-carbon of the amino acid, and a hydrochloride counterion. L-Alanine methyl ester hydrochloride is known for its stability and solubility in aqueous solutions, making it a useful compound in various applications.

Uses

Used in Pharmaceutical Industry:
L-Alanine methyl ester hydrochloride is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows for the development of new drugs with potential applications in treating a range of medical conditions.
Used in Diagnostic Applications:
L-Alanine methyl ester hydrochloride is used as a diagnostic aid for in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes. Its ability to be easily detected and monitored in the body makes it a valuable tool for understanding the metabolic processes in diabetic patients and for the development of new treatments for diabetes.
Used in Research and Development:
Due to its unique chemical properties, L-Alanine methyl ester hydrochloride is used in research and development for the study of amino acid metabolism, protein synthesis, and other biological processes. It can also be used as a building block for the synthesis of novel peptides and other bioactive molecules with potential applications in medicine and biotechnology.
Used in Chemical Synthesis:
L-Alanine methyl ester hydrochloride is used as a reagent in various chemical synthesis processes, particularly in the production of chiral compounds. Its optical activity and stability make it a valuable starting material for the synthesis of enantiomerically pure compounds, which are important in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C4H9NO2/c1-3(5)4(6)7-2/h3H,5H2,1-2H3/p+1/t3-/m0/s1

Upstream product

• 67-56-1 methanol 
• 56-41-7 L-alanin 
• 912290-10-9 methyl N-p-dimethylaminobenzylidenealaninate 
• 83575-33-1 Sulfuric acid (3aR,5R,6S,6aR)-5-(2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester methyl ester 
• 28875-17-4 (S)-N-(tert-butoxycarbonyl)alanine methyl ester 
• 6003-05-0 L-alanine hydrochloride 
• 15761-38-3 L-N-Boc-Ala 
• 129178-93-4 L-alanine acid chloride 
• 74-88-4 methyl iodide 
• 77-76-9 2,2-dimethoxy-propane 
• 75-36-5 acetyl chloride 
• 10065-72-2 L-Alanine methyl ester 
• 13515-97-4 methyl 2-aminopropanoate monohydrochloride 
• 28819-05-8 (S)-2-benzyloxycarbonylamino-propionic acid methyl ester 

Downstream Products

• 21679-94-7 N-(S-benzyl-N-benzyloxycarbonyl-L-cysteinyl)-L-alanine methyl ester 
• 28944-94-7 (S)-methyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoate 
• 3480-80-6 N-benzyloxycarbonyl-glycyl=>D-phenylalanyl=>L-alanine 
• 80514-64-3 2-(tritylamino)propanoic acid 
• 29429-31-0 N-(N-trityl-L-seryl)-L-alanine methyl ester 
• 19794-10-6 (S)-methyl 2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate 
• 56120-14-0 methyl N-(3-(((benzyloxy)carbonyl)amino)propanoyl)-L-alaninate 
• 22839-06-1 Boc-Lys(Z)-Ala-OMe 
• 52071-20-2 N-Boc-S-trityl-L-cys-L-ala-OMe 
• 19914-27-3 N-benzyloxycarbonyl-D-alaninyl-L-alanine methyl ester 
• 1803-59-4 Z-D-Leu-L-Ala-OCH₃ 
• 16816-28-7 methyl 2-[({[(benzyloxy)carbonyl]amino}acetyl)amino]propanoate 
• 2483-53-6 Z-Thr-Ala-OMe 
• 13850-69-6 N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-L-alanine methyl ester 

Relevant articles and documents

Development of a prodrug of salicylic acid, salicylic Acid-L-alanine conjugate, utilizing hydrolysis by rabbit intestinal microorganisms

The hydrolysis of salicylic acid-L-alanine conjugate (salicyl-L-alanine) following oral, intravenous, intracaecal and rectal administration (60, 10, 5 and 5 mg kg-1 respectively: salicylic acid equivalent) was examined in rabbits. Salicylic acid was detected in the blood 2 h after oral administration of salicyl-L-alanine and reached a maximum concentration at 10 h, whereas salicyl-L-alanine was rapidly eliminated. In contrast, unchanged salicyl-L-alanine only was found following intravenous administration of salicyl-L-alanine, suggesting that presystemic de-conjugation of salicyl-L-alanine was involved. The intestinal mucosal de-conjugation of salicyl-L-alanine was not recognized in the in-situ intestinal sac preparation with complete mesenteric venous blood collection. Immediate and very extensive salicylic acid formation in the caecum was found following intracaecal administration of salicyl-L-alanine. After oral pretreatment of rabbits with kanamycin sulphate, a significant inhibition of salicylic acid formation following intracaecal administration of salicyl-L-alanine was observed, indicating that the intestinal microorganisms were responsible for the biotransformation of salicyl-L-alanine. In-vitro incubation of salicyl-L-alanine with gut contents showed that the major source of its hydrolysis was the hind gut. Consequently, the blood concentration of salicylic acid was prolonged extensively following rectal administration of salicyl-L-alanine, suggesting the usefulness of salicyl-L-alanine as a prodrug of salicylic acid.

Three new metabolites from the endophytic fungus Climacocystis montana isolated from the root bark of Paeonia ostia

Two new pyridine derivatives climacomontaninates A–B (1–2), and a new sesquiterpenoid derivative climacomontanetate (3), together with twelve known compounds (4–15) were isolated from the culture extract of the fungal strain Climacocystis montana from the root bark of Paeonia ostii. The structures of these compounds were determined through spectroscopic methods such as NMR and HRMS. Moreover, we expound the absolute configuration of 1 using the organic synthesis method. The cytotoxicity against five human cancer cell lines of new compounds were evaluated by SRB assay.

Triazolyl-donor-acceptor chromophore-decorated unnatural amino acids and peptides: FRET events in a β-turn conformation

The β-turn conformation and FRET process were established in the designed tripeptide containing fluorescent triazolyl donor and acceptor-decorated unnatural amino acids separated by a natural alanine.

Novel emissive bio-inspired non-proteinogenic coumarin-Alanine amino acid: Fluorescent probe for polyfunctional systems

Two new bio-inspired non-proteinogenic compounds L1 and L2, containing coumarin and/or acridine chromophores and bearing as spacer an alanine amino acid were successfully synthesized and fully characterized by elemental analysis, 1H and 13

Design and synthesis of hydrophobic and chiral anions from amino acids as precursor for functional ionic liquids

Hydrophobic ionic liquids composed of tetrabutylphosphonium cation and chiral anions derived from amino acids modified with trifluoromethane sulfonyl groups have been synthesized using a simple method. The Royal Society of Chemistry 2006.

Multiple alkylation and mapping of the active site of α-chymotrypsin by carbonium ions generated with active-site-directed enzyme-activated nitrosoamide substrates

The inhibition of α-chymotrypsin with 13C-enriched alanine- and phenylalanine-based N-nitrosoamides, as active-site-directed and enzyme-activated inhibitors, results in the alkylation (benzylation) of side chains and also of the amide linkages of the protein backbone (both at O and N). 13C NMR spectra of the denatured inhibited enzyme (in Gdn.HCl) indicate that alkylation has occurred at O, N, S, and C sites. 13C NMR spectra of the amino acid mixtures from fully hydrolyzed inhibited enzymes show that the pattern of alkylation is strikingly different for inhibitions by the alanine- and phenylalanine-based inhibitors. In the case of the phenylalanine-based inhibitor, approximately equally intense signals are observed at 52.32, 51.31, 36.78, and 32.91 ppm, while with the alanine-based inhibitor, a major signal appears at 52.35 ppm, with minor signals appearing at 36.83 and 32.9 ppm. Chromatographic and NMR evidence is presented to indicate that the 52.32-52.35-ppm signal stems from N-benzylglycine. The chemical shift data suggest that the 51.31-ppm signal stems from N-benzylserine and the 36.78-36.83-ppm signal from S-benzylcysteine. Mechanisms are presented to account for the formation of those products.

Straightforward Synthesis of Fluorinated Enals via Photocatalytic α-Perfluoroalkenylation of Aldehydes

(Per)fluorinated substances represent an important compound class with regard to drug design and material chemistry. We found a mild, operationally simple, and inexpensive photocatalytic perfluoroalkenylation reaction giving tetrasubstituted, highly electron-deficient enals straight from aldehydes. This one-step reaction tolerates various functional groups and can be applied to a wide range of substrates giving the products in yields of 52-84%.

N-Alkenylation of hydroxamic acid derivatives with ethynyl benziodoxolone to synthesizecis-enamides through vinyl benziodoxolones

The stereoselective synthesis ofcis-β-N-alkoxyamidevinyl benziodoxolones (cis-β-N-RO-amide-VBXs) fromO-alkyl hydroxamic acids in the presence of an ethynyl benziodoxolone-acetonitrile complex (EBX-MeCN) is reported herein. The reaction was performed under mild conditions including an aqueous solvent, a mild base, and room temperature. The reaction tolerated variousO-alkyl hydroxamic acids derived from carboxylic acids, such as amino acids, pharmaceuticals, and natural products. Vinyl dideuteratedcis-β-N-MeO-amide-VBXs were also synthesized using deuterium oxide as the deuterium source. Valine-derivedcis-β-N-MeO-amide-VBX was stereospecifically derivatized to hydroxamic acid-derivedcis-enamides without the loss of stereoselectivity or reduction in the deuterium/hydrogen ratio.