2498-48-8

Basic information

• Product Name: cyclohexanecarboximidamide
• CAS NO: 2498-48-8
• Molecular Formula: C₇H₁₄N₂*ClH
• Molecular Weight: 126.1995
• Mol File: 2498-48-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 204.9°C at 760 mmHg
• Flash Point: 77.7°C
• Density: 1.14g/cm³
• Vapor Pressure: 0.257mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: cyclohexanecarboximidamide(CAS DataBase Reference)
• NIST Chemistry Reference: cyclohexanecarboximidamide(2498-48-8)
• EPA Substance Registry System: cyclohexanecarboximidamide(2498-48-8)

Safety Data

• Hazardous Substances Data: 2498-48-8(Hazardous Substances Data)

Upstream product

• 94052-40-1 methyl cyclohexanecarboximidate hydrochloride 
• 766-05-2 cyclohexane carbonitrile 
• 75-36-5 acetyl chloride 
• 66493-03-6 methyl cyclohexanecarboximidate 

Downstream Products

• 94052-07-0 2-cyclohexyl-6-methylpyrimidin-4(3H)-one 
• 123837-54-7 2-Cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester 
• 94052-08-1 2-cyclohexyl-6-hydroxypyrimidin-4(3H)-one 
• 203914-80-1 2-Cyclohexyl-5,6,7,8-tetrahydro-quinazoline 
• 1003587-19-6 2-cyclohexyl-6-(3-phenyl-propyl)-pyrimidin-4-ol 
• 1003587-70-9 2-cyclohexyl-6-hydroxy-5-methyl-pyrimidine-4-carboxylic acid ethyl ester 
• 203914-87-8 [2-Cyclohexyl-6,7-dihydro-5H-quinazolin-(8E)-ylidene]-acetic acid methyl ester 
• 94052-09-2 4-chloro-2-cyclohexyl-6-methylpyrimidine 
• 94052-11-6 2,6-dichloro-2-cyclohexylpyrimidine 
• 94052-23-0 2-(2'-cyclohexyl-6'-methylpyrimidin-4'-ylthio)-N,N-dimethylethylamine 
• 94052-24-1 2-<2'-cyclohexyl-6'-(2''-dimethylaminoethylthio)pyrimidin-4'-ylthio>-N,N-dimethylethylamine 
• 123837-63-8 [2-Cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidin-5-yl]-methanol 
• 123837-66-1 5-Bromomethyl-2-cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidine 
• 123837-60-5 2-Cyclohexyl-4-(4-fluoro-phenyl)-6-isopropyl-pyrimidine-5-carboxylic acid ethyl ester 

Relevant articles and documents

Guanidine Synthesis: Use of Amidines as Guanylating Agents

The use of amidines for the tandem or one-pot synthesis of guanidines is reported. Guanidines are obtained by oxidative rearrangement of readily available and stable amidines into carbodiimides, followed by in situ reaction with amines. The protocol can be executed under mild reaction conditions (30°C), in a green solvent (dimethyl carbonate). The amine scope is broad, including sterically hindered, oxidation-sensitive and chiral amines. Examples for the synthesis of both acyclic and cyclic guanidines are provided. 2-Propoxyphenyl iodide (2-PrOPhI) by-product, generated from the oxidant [N-(p-toluenesulfonyl)imino](2-propoxyphenyl)iodinane (2-PrOPhINTs), can be isolated in high yields making regeneration of the hypervalent iodine reagent possible. The utility and greenness of the synthetic method versus the state-of-the-art is demonstrated by a new route towards the antihypertensive drug Pinacidil. The process mass intensity (PMI) of the new route is only 24% of the classical one.

AMINOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES

The present invention relates to compounds of formula I useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention

2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic acid aldose reductase inhibitors

Disclosed herein are 2,4-disubstituted-5-cyano-1,6-dihydro-6-oxo-1-pyrimidineacetic acids and pharmaceutically acceptable salts thereof and methods of their preparation. The compounds are new aldose reductase inhibitors useful for the treatment or prevention of diabetic complications.