250-94-2

Basic information

• Product Name: 4H-THIENO[3,2-B]PYRROLE
• Synonyms: 4H-THIENO[3,2-B]PYRROLE
• CAS NO: 250-94-2
• Molecular Formula: C₆H₅NS
• Molecular Weight: 123.1756
• EINECS: -0
• Mol File: 250-94-2.mol
• Article Data: 1

Chemical Properties

• Melting Point: 30-35 °C
• Boiling Point: 261.3±13.0 °C(Predicted)
• Appearance: /
• Density: 1.348±0.06 g/cm3(Predicted)
• PKA: 16?+-.0.30(Predicted)
• CAS DataBase Reference: 4H-THIENO[3,2-B]PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-THIENO[3,2-B]PYRROLE(250-94-2)
• EPA Substance Registry System: 4H-THIENO[3,2-B]PYRROLE(250-94-2)

Safety Data

• Hazardous Substances Data: 250-94-2(Hazardous Substances Data)

Upstream product

• 82782-85-2 thieno<3,2-b>pyrrole-5-carboxylic acid methyl ester 

Relevant articles and documents

Chemical Evolution of a Bacterial Proteome

We have changed the amino acid set of the genetic code of Escherichia coli by evolving cultures capable of growing on the synthetic noncanonical amino acid L-β-(thieno[3,2-b]pyrrolyl)alanine ([3,2]Tpa) as a sole surrogate for the canonical amino acid L-tryptophan (Trp). A long-term cultivation experiment in defined synthetic media resulted in the evolution of cells capable of surviving Trp→[3,2]Tpa substitutions in their proteomes in response to the 20 899 TGG codons of the E. coli W3110 genome. These evolved bacteria with new-to-nature amino acid composition showed robust growth in the complete absence of Trp. Our experimental results illustrate an approach for the evolution of synthetic cells with alternative biochemical building blocks.