25062-90-2Relevant articles and documents
Selective Late-Stage Oxygenation of Sulfides with Ground-State Oxygen by Uranyl Photocatalysis
Li, Yiming,Rizvi, S. Aal-e-Ali,Hu, Deqing,Sun, Danwen,Gao, Anhui,Zhou, Yubo,Li, Jia,Jiang, Xuefeng
supporting information, p. 13499 - 13506 (2019/08/21)
Oxygenation is a fundamental transformation in synthesis. Herein, we describe the selective late-stage oxygenation of sulfur-containing complex molecules with ground-state oxygen under ambient conditions. The high oxidation potential of the active uranyl cation (UO22+) enabled the efficient synthesis of sulfones. The ligand-to-metal charge transfer process (LMCT) from O 2p to U 5f within the O=U=O group, which generates a UV center and an oxygen radical, is assumed to be affected by the solvent and additives, and can be tuned to promote selective sulfoxidation. This tunable strategy enabled the batch synthesis of 32 pharmaceuticals and analogues by late-stage oxygenation in an atom- and step-efficient manner.
Synthesizing method of 3-sulfonyl alcohol compounds
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Paragraph 0014, (2017/04/03)
The invention discloses a synthesizing method of 3-sulfonyl alcohol compound. The method includes: using substituted sulfohydrazide and propenol compounds as the raw materials to perform reaction in water so as to obtain the 3-sulfonyl alcohol compounds. The method has the advantages that the method uses the substituted sulfohydrazide and the propenol compounds as the raw materials to perform the heating reaction in an aqueous solution without catalysts to directly obtain the 3-sulfonyl alcohol compounds, and the 3-sulfonyl alcohol compounds with the purity being above 80% can be obtained through simple separation after the reaction; the method is few in steps, simple to operate and green, and a new method for synthesizing medical and chemical alcohol compounds is provided for the chemical synthesizing field.
Fluorine-18 Radiolabeling and Radiopharmacological Characterization of a Benzodioxolylpyrimidine-based Radiotracer Targeting the Receptor Tyrosine Kinase EphB4
Mamat, Constantin,Mosch, Birgit,Neuber, Christin,K?ckerling, Martin,Bergmann, Ralf,Pietzsch, Jens
, p. 1991 - 2003 (2013/01/15)
Members of the Eph receptor tyrosine kinase family play essential roles in the pathogenesis of cancer and are therefore promising candidates for molecular imaging by positron emission tomography (PET), for example. In this regard, radiochemical access to
