25063-43-8Relevant articles and documents
Development of novel quinoline-based sulfonamides as selective cancer-associated carbonic anhydrase isoform ix inhibitors
Shaldam, Moataz,Nocentini, Alessio,Elsayed, Zainab M.,Ibrahim, Tamer M.,Salem, Rofaida,El-Domany, Ramadan A.,Capasso, Clemente,Supuran, Claudiu T.,Eldehna, Wagdy M.
, (2021/10/19)
A new series of quinoline-based benzenesulfonamides (QBS) were developed as potential carbonic anhydrase inhibitors (CAIs). The target QBS CAIs is based on the 4-anilinoquinoline scaffold where the primary sulphonamide functionality was grafted at C4 of t
Differential characterization using readily accessible NMR experiments of novel N- and O-alkylated quinolin-4-ol, 1,5-naphthyridin-4-ol and quinazolin-4-ol derivatives with antimycobacterial activity
Pitta, Eleni,Balabon, Olga,Rogacki, Maciej K.,Gómez, Jesús,Cunningham, Fraser,Joosens, Jurgen,Augustyns, Koen,van der Veken, Pieter,Bates, Robert
, p. 890 - 901 (2016/10/25)
During the construction of bioactive molecules, regioselective alkylation of heterocyclic, N/O ambident nucleophiles is a frequently encountered synthetic transformation. In this framework, specific attention is required to unambiguously determine the str
The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives
Tukulula, Matshawandile,Little, Susan,Gut, Jiri,Rosenthal, Philip J.,Wan, Baojie,Franzblau, Scott G.,Chibale, Kelly
, p. 259 - 267 (2013/01/15)
A series of new arylamino quinoline derivatives was designed based on the quinine and mefloquine scaffolds and evaluated in vitro for antiplasmodial and antimycobacterial activities. A number of these compounds exhibited significant activity against the d
