250685-44-0

Basic information

• Product Name: 8-(1-NAPHTHALENYLMETHYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECANE-3-ACETIC ACID, METHYL ESTER
• Synonyms: NNC 63-0532;8-(1-NAPHTHALENYLMETHYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECANE-3-ACETIC ACID, METHYL ESTER
• CAS NO: 250685-44-0
• Molecular Formula: C27H29N3O3
• Molecular Weight: 443.54
• Product Categories: Opioid receptor and opioid-like receptor
• Mol File: 250685-44-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 645.8°Cat760mmHg
• Flash Point: 344.4°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 1.44E-16mmHg at 25°C
• Refractive Index: 1.675
• Storage Temp.: Store at RT
• CAS DataBase Reference: 8-(1-NAPHTHALENYLMETHYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECANE-3-ACETIC ACID, METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(1-NAPHTHALENYLMETHYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECANE-3-ACETIC ACID, METHYL ESTER(250685-44-0)
• EPA Substance Registry System: 8-(1-NAPHTHALENYLMETHYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECANE-3-ACETIC ACID, METHYL ESTER(250685-44-0)

Safety Data

• Hazardous Substances Data: 250685-44-0(Hazardous Substances Data)

Usage

Description

8-(1-NAPHTHALENYLMETHYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECANE-3-ACETIC ACID, METHYL ESTER is a complex organic compound with a unique molecular structure. It is characterized by its potent agonistic activity towards the nociceptin receptor, which plays a significant role in various physiological processes.

Uses

Used in Pharmaceutical Industry:
8-(1-NAPHTHALENYLMETHYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECANE-3-ACETIC ACID, METHYL ESTER is used as a potent nociceptin receptor agonist for the development of therapeutic agents targeting pain management and other related conditions. Its agonistic activity on the nociceptin receptor can potentially lead to the modulation of pain perception and the treatment of various pain-related disorders.
Used in Research Applications:
In the field of scientific research, 8-(1-NAPHTHALENYLMETHYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECANE-3-ACETIC ACID, METHYL ESTER serves as an important tool for studying the function and role of the nociceptin receptor in various physiological and pathological processes. 8-(1-NAPHTHALENYLMETHYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECANE-3-ACETIC ACID, METHYL ESTER can be utilized to investigate the underlying mechanisms of pain, addiction, stress response, and other related conditions, contributing to a better understanding of these complex biological phenomena.
Please note that the provided materials do not mention any other specific applications or industries for 8-(1-NAPHTHALENYLMETHYL)-4-OXO-1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECANE-3-ACETIC ACID, METHYL ESTER. The uses listed above are based on the information given and the general knowledge of such compounds in the pharmaceutical and research fields.

Biological Activity

Potent non-peptide agonist for the NOP receptor (EC 50 = 305 nM, K i = 7.3 nM); ~ 12-fold selective over other receptors. Centrally active following systemic administration in vivo .

InChI:InChI=1/C27H29N3O3/c1-33-25(31)19-29-20-30(24-9-3-2-4-10-24)27(26(29)32)13-15-28(16-14-27)18-21-11-12-22-7-5-6-8-23(22)17-21/h2-12,17H,13-16,18-20H2,1H3

Upstream product

• 250685-84-8 8Naphthalen-1-ylmethyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 
• 96-32-2 bromoacetic acid methyl ester 
• 1021-25-6 1-Phenyl-1,3,8-triaza-spiro[4.5]decan-4-one 
• 86-52-2 1-Chloromethylnaphthalene 

Relevant articles and documents

1,3,8-triazaspiro[4.5]decanones with high affinity for opioid receptor subtypes

The present invention relates to the use of small organic compounds acting as opioid receptor ligands for the treatment of vasomotor disturbances. In particular the present invention relates to the use of triaza-spiro compounds of formula wherein R1