25123-05-1

Basic information

• Product Name: Propionic acid (3R)-1,3β-dimethyl-4-phenylpiperidine-4α-yl ester
• Synonyms: (-)-Propionic acid (3R,4R)-1,3-dimethyl-4-phenylpiperidin-4-yl ester;Propionic acid (3R)-1,3β-dimethyl-4-phenylpiperidine-4α-yl ester
• CAS NO: 25123-05-1
• Molecular Formula: C₁₆H₂₃NO₂
• Molecular Weight: 261.36
• Mol File: 25123-05-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Propionic acid (3R)-1,3β-dimethyl-4-phenylpiperidine-4α-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propionic acid (3R)-1,3β-dimethyl-4-phenylpiperidine-4α-yl ester(25123-05-1)
• EPA Substance Registry System: Propionic acid (3R)-1,3β-dimethyl-4-phenylpiperidine-4α-yl ester(25123-05-1)

Safety Data

• Hazardous Substances Data: 25123-05-1(Hazardous Substances Data)

Upstream product

• 4629-80-5 1,3-dimethyl-4-piperidinone 
• 108-74-7 1,3,5-trimethyl-1,3,5-triazacyclohexane 
• 2039-93-2 1-ethylstyrene 
• 123-62-6 propionic acid anhydride 
• 51412-30-7 6-ethyl-3-methyl-6-phenyl-[1,3]oxazinane 
• 46366-96-5 (-)-β-prodinol 

Downstream Products

• 109765-68-6 (+/-)-α-4-hydroxy-3-methyl-4-phenylpiperidine 
• 37083-28-6 α-4-hydroxy-3-methyl-4-phenyl-1-propanoylpiperidine 
• 140163-04-8 (+/-)-α-1-(1-cyanocyclohexyl)-4-hydroxy-3-methyl-4-phenylpiperidine 
• 140163-06-0 (+/-)-α-4-hydroxy-3-methyl-4-phenyl-1-(1-phenylcyclohexyl)piperidine 
• 140163-08-2 (+/-)-α-4-acetoxy-3-methyl-4-phenyl-1-(1-phenylcyclohexyl)piperidine 

Relevant articles and documents

The morphine-like and nonmorphine-like conformers of prodine opioids

The compounds α-, and β-prodine and their meta hydroxylated analogs were synthesized, resolved, and screened for affinity at opioid receptor subtypes. The compounds primarily have affinity for μ-receptors. The μ-receptor affinities of the nonmorphine-like (+)-enantiomers, which have the greater antinociceptive activity, are reduced by the presence of a meta hydroxyl while the affinities for all opioid receptor subtypes of the morphine-like, but less active, (-)-enantiomers are enhanced or unchanged. Both enantiomers of meta-hydroxylated β-prodine had antagonist activity in the guinea pig ileum assay.