25125-72-8 Usage
Description
(2R,3R)-2,3-diphenylaziridine is a chiral aziridine compound belonging to the class of three-membered heterocyclic compounds that contain a nitrogen atom. As a chiral molecule, it features two stereocenters and exists in pairs of enantiomers. (2R,3R)-2,3-diphenylaziridine has garnered significant interest due to its potential applications across various fields, including organic synthesis, pharmaceuticals, and materials science. Its unique structure and reactivity position it as a valuable asset in the realm of organic chemistry, particularly for the synthesis of biologically active molecules and its use as a catalyst in asymmetric synthesis reactions.
Uses
Used in Organic Synthesis:
(2R,3R)-2,3-diphenylaziridine serves as a crucial building block in the synthesis of a variety of biologically active molecules. Its presence in these syntheses is attributed to its distinctive structural features and reactivity, which facilitate the creation of complex organic compounds with potential applications in medicine and other industries.
Used in Pharmaceutical Development:
In the pharmaceutical industry, (2R,3R)-2,3-diphenylaziridine is utilized for its potential to contribute to the development of new drugs. Its unique properties allow it to be a key component in the creation of molecules that can interact with biological targets, potentially leading to the discovery of novel therapeutic agents.
Used in Materials Science:
(2R,3R)-2,3-diphenylaziridine also finds application in materials science, where its distinctive chemical properties can be harnessed to develop new materials with specific characteristics. These materials could have uses in various high-tech applications, such as in the creation of advanced polymers or other specialized materials.
Used as a Catalyst in Asymmetric Synthesis Reactions:
(2R,3R)-2,3-diphenylaziridine is employed as a catalyst in asymmetric synthesis reactions, a critical process in the production of enantiomerically pure compounds. Its role as a catalyst is significant for enhancing the selectivity and efficiency of these reactions, which is particularly important in the synthesis of pharmaceuticals and other chiral molecules where the specific three-dimensional arrangement of atoms is crucial for biological activity.
Check Digit Verification of cas no
The CAS Registry Mumber 25125-72-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,1,2 and 5 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 25125-72:
(7*2)+(6*5)+(5*1)+(4*2)+(3*5)+(2*7)+(1*2)=88
88 % 10 = 8
So 25125-72-8 is a valid CAS Registry Number.
25125-72-8Relevant articles and documents
Chiral sulfide - phosphine ligand and preparation method and use thereof
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Paragraph 0059; 0069; 0079; 0089; 0099; 0109; 0120, (2017/08/25)
The present invention provides a novel chiral thioether-phosphine ligand and a preparation method and application thereof. The ligand is a compound shown as a formula I, or enantiomer, non-enantiomer, racemate, pharmaceutically acceptable salt, hydrate and solvate crystal thereof. R1 is an optionally substituted phenyl, and optionally substituted naphthyl; and R2 is methyl and benzyl. The chiral thioether-phosphine ligand provided by the invention as a copper-catalyzed asymmetric cycloaddition ligand can be directly used to prepare various pyrrolidine compounds with substituted multiple chiral centers.
Enantioselective synthesis of tetrahydrofuran derivatives by sequential henry reaction and iodocyclization of γ,δ-unsaturated alcohols
Chen, Li-Yan,Chen, Jia-Rong,Cheng, Hong-Gang,Lu, Liang-Qiu,Xiao, Wen-Jing
supporting information, p. 4714 - 4719 (2014/08/05)
A sequential one-pot Cu-catalyzed asymmetric Henry reaction and iodocyclization is disclosed. The transformation provides efficient access to biologically and synthetically useful 2,2,5-trisubstituted tetrahydrofuran derivatives. The combination of Cu(OAc)2·H2O with a novel chiral sulfoxide-Schiff base hybrid ligand under mild reaction conditions tolerates a wide range of 4-substituted γ,δ-unsaturated aldehydes, and the subsequent iodocyclization furnishes the corresponding products in generally high yields with excellent enantioselectivities. The products can be easily converted into amines with excellent diastereo- and enantioselectivities.
2-(p-Tolylsulfinyl)benzyl halides as efficient precursors of optically pure trans-2,3-Disubstituted aziridines
Arroyo, Yolanda,Meana, Angela,Sanz-Tejedor, M. Ascension,Alonso, Ines,Garcia Ruano, Jose Luis
experimental part, p. 9874 - 9883 (2010/10/04)
Aziridination of (R)-N-sulfinylaldimines (aryl, heteroaryl and alkenyl derivatives) with 2-(p-tolyl sulfinyl)benzyl iodide in the presence of sodium hexamethyl disilazide takes place with almost complete control of the stereoselectivity (facial and antil
