25173-09-5

Basic information

• Product Name: 2-phenyl-N,N-dipropylacetamide
• CAS NO: 25173-09-5
• Molecular Formula: C₁₄H₂₁NO
• Molecular Weight: 219.3226
• Mol File: 25173-09-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 339.2°C at 760 mmHg
• Flash Point: 146.9°C
• Density: 0.971g/cm³
• Vapor Pressure: 9.32E-05mmHg at 25°C
• Refractive Index: 1.508
• CAS DataBase Reference: 2-phenyl-N,N-dipropylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-N,N-dipropylacetamide(25173-09-5)
• EPA Substance Registry System: 2-phenyl-N,N-dipropylacetamide(25173-09-5)

Safety Data

• Hazardous Substances Data: 25173-09-5(Hazardous Substances Data)

Upstream product

• 142-84-7 di-n-propylamine 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 60-12-8 2-phenylethanol 
• 201230-82-2 carbon monoxide 
• 20441-12-7 N-benzyl-N,N-dipropylamine 

Downstream Products

• 23916-02-1 N-2-(phenylethyl)-N,N-dipropyl-amine 

Relevant articles and documents

Efficient and accessible silane-mediated direct amide coupling of carboxylic acids and amines

A straightforward method for the direct synthesis of amides from amines and carboxylic acids without exclusion of air or moisture using diphenylsilane with N-methylpyrrolidine has been developed. Various amides are made efficiently, and broad functional group compatibility is shown through a Glorius robustness study. A gram-scale synthesis demonstrates the scalability of this method. This journal is

Direct amidation of carboxylic acids with tertiary amines: Amide formation over copper catalysts through C-N bond cleavage

A copper-catalyzed system for the amidation of carboxylic acids with tert-amines through C-N bond cleavage was developed. This protocol is practical and represents a simple way to produce functionalized amides from basic starting materials in moderate to good yields. A plausible mechanism is proposed for the reaction. Copyright

N-heterocyclic carbene based ruthenium-catalyzed direct amide synthesis from alcohols and secondary amines: Involvement of esters

A well-defined N-heterocyclic carbene based ruthenium complex was developed as a highly active precatalyst for the direct amide synthesis from alcohols and secondary amines. Notably, reaction of 1-hexanol and dibenzylamine afforded 60% of the corresponding amide using our catalytic system, while no amide formation was observed for this reaction with the previously reported catalytic systems. Unlike the previously reported amidation with less sterically hindered alcohols and amines, involvement of ester intermediates was observed (Figure presented).