252210-01-8Relevant articles and documents
BIVALENT TARGETED CONJUGATES
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, (2020/05/28)
The invention provides conjugates that comprise a bivalent targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates, compositions comprising the bidentate targeting ligands and the conjugates, as well as methods for targeting therapeutic nucleic acids with the bidentate conjugates. The conjugates are useful to target therapeutic nucleic acids.
Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor
Pegoli, Andrea,She, Xueke,Wifling, David,Hübner, Harald,Bernhardt, Günther,Gmeiner, Peter,Keller, Max
, p. 3314 - 3334 (2017/05/05)
The dualsteric ligand approach, aiming at ligands with improved subtype selectivity, has been increasingly applied to muscarinic receptors (MRs). In this article, we present the synthesis and characterization of a M2R subtype-preferring radiola
Peptide dendrimers with designer core for directed self-assembly
Verma, Ram P.,Shandilya, Ashutosh,Haridas
, p. 8758 - 8765 (2015/10/20)
A series of designer peptide dendrimers with urea and urea-triazole cores were synthesized. Urea cored dendrimers assembled into fibrillar morphology, while dendrimers with urea-triazole core assembled into vesicular morphology. The core-dependent self-as