25244-68-2

Basic information

• Product Name: PHENOTHIAZINE-10-ACETIC ACID
• Synonyms: PHENOTHIAZINE-10-ACETIC ACID;10H-phenothiazin-10-ylacetic acid;Phenothiazin-10-yl-acetic acid
• CAS NO: 25244-68-2
• Molecular Formula: C₁₄H₁₁NO₂S
• Molecular Weight: 257.31
• Product Categories: pharmacetical
• Mol File: 25244-68-2.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 464.7 °C at 760 mmHg
• Flash Point: 234.9 °C
• Appearance: /
• Density: 1.362 g/cm³
• Vapor Pressure: 1.95E-09mmHg at 25°C
• Refractive Index: 1.685
• Storage Temp.: 2-8°C
• PKA: 3.69±0.10(Predicted)
• CAS DataBase Reference: PHENOTHIAZINE-10-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: PHENOTHIAZINE-10-ACETIC ACID(25244-68-2)
• EPA Substance Registry System: PHENOTHIAZINE-10-ACETIC ACID(25244-68-2)

Safety Data

• Hazardous Substances Data: 25244-68-2(Hazardous Substances Data)

Usage

General Description

PHENOTHIAZINE-10-ACETIC ACID is a chemical compound with potential antipsychotic properties. It is a derivative of phenothiazine, which is known for its antipsychotic effects. PHENOTHIAZINE-10-ACETIC ACID acts as a dopamine receptor antagonist and has been studied for its potential use in the treatment of schizophrenia and other psychotic disorders. It is also being investigated for its potential anti-inflammatory and anti-cancer properties. PHENOTHIAZINE-10-ACETIC ACID is still in the early stages of research, but it shows promise for its potential therapeutic applications in mental health and oncology.

InChI:InChI=1/C14H11NO2S/c16-14(17)9-15-10-5-1-3-7-12(10)18-13-8-4-2-6-11(13)15/h1-8H,9H2,(H,16,17)

Upstream product

• 68825-29-6 ethyl 2-(10H-phenothiazin-10-yl)acetate 
• 92-84-2 10H-phenothiazine 
• 79-08-3 bromoacetic acid 
• 79-11-8 chloroacetic acid 
• 105-36-2 ethyl bromoacetate 
• 295801-35-3 tert-butyl 2-(10-phenothiazinyl)acetate 
• 7748-25-6 potassium chloroacetate 

Downstream Products

• 1207-72-3 N-methylphenothiazine 
• 158502-05-7 phenothiazino-10-acetyl chloride 
• 929617-19-6 11-{4-[(2-phenothiazin-10-yl-acetylamino)methyl]benzyl}-1,4,8-tri(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane 
• 1345036-63-6 C₂₀H₁₀F₅NO₂S 
• 1345036-72-7 Fmoc-aeg(Ptz)-OPfp 
• 1390635-98-9 {1-[2-(4-cyanophenyl)-2-oxoethyl]-1H-1,2,3-triazol-4-yl}methyl 10H-phenothiazin-10-ylacetate 
• 1421688-61-0 PTZ-GFFY 
• 15375-56-1 1-(10H-phenothiazin-10-yl)propan-2-one 
• 1613229-94-9 1-(10H-phenothiazin-10-yl)acetone N-phenylsemicarbazone 
• 942031-73-4 5-((10H-phenothiazin-10-yl)methyl)-4-(4-chlorobenzylideneamino)-4H-1,2,4-triazole-3-thiol 

Relevant articles and documents

Rapid N-alkylation of carbazole, phenothiazine and acridone under microwave irradiation

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Synthesis of Novel β-Lactams from Phenothiazin-10-ylacetic Acid

The first synthesis of 3-phenothiazine-β-lactams is herein reported. Thirteen new derivatives of β-lactams were synthesized using various Schiff bases and (phenothiazin-10-yl)acetic acid, which in turn was prepared starting from phenothiazine. The sole product of the Staudinger ketene–imine [2?+?2] cycloaddition reaction is the trans-β-lactam. All the synthesized compounds were characterized by elemental analyses and spectral (IR, 1H-NMR, and 13C-NMR) data.

N of a kind of preparation method of-carbencillin methyl phenothiazine

The invention relates to a method for preparing N-carboxymethyl phenothiazine, which comprises the following steps: directly mixing phenothiazine, potassium chloroacetate and N,N-dimethyl formamide, and heating while adjusting the pH value to 8-9; cooling the reaction liquid and adjusting to strong acidity, and adding the solution into water to obtain a product. According to the method provided by the invention, phenothiazine and potassium chloroacetate are used as raw materials, the product is synthesized by one step, the reaction time is short, the reaction process is simple, and the operation is easy; moreover, the conversion rate of the raw materials is very high, the yield of the obtained product exceeds 95%, and the new design thought provides more application space for the synthesis of N-carboxymethyl phenothiazine.

INHIBITORS OF MALT1 PROTEASE

The present invention relates to compounds which are inhibitors of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALTl) and to their use in therapy, in particular in the treatment or prevention of a disease or disorder which is treatable by an inhibitor of a paracaspase. The present invention also relates to pharmaceutical compositions containing such compounds.