25315-41-7Relevant articles and documents
Silver-catalyzed oxidative decarboxylation of difluoroacetates: Efficient access to C-CF2 bond formation
Wan, Wen,Ma, Guobin,Li, Jialiang,Chen, Yunrong,Hu, Qingyang,Li, Minjie,Jiang, Haizhen,Deng, Hongmei,Hao, Jian
, p. 1598 - 1601 (2016)
A mild, versatile and efficient method for the silver(i)-catalyzed oxidative decarboxylative gem-difluoromethylenation has been developed. The radical cascade reaction comprises the addition of an oxidatively generated difluoromethylene radical to the isonitrile functionality and subsequent homolytic aromatic substitution. It provides a novel and efficient access to the C-CF2 bond formation.
Metal-Free Radical Cyclization of Vinyl Isocyanides with Alkanes: Synthesis of 1-Alkylisoquinolines
Xue, Dengqi,Xue, Yijie,Yu, Haihua,Shao, Liming
supporting information, p. 874 - 884 (2019/02/10)
A metal-free radical cyclization reaction of vinyl isocyanides with alkanes is developed, allowing convenient access to a diverse range of potentially valuable 1-alkylisoquinolines. The methodology is simple and efficient, demonstrating excellent functional group tolerance and broad substrate scope. A mechanism involving a radical process is supported by kinetic isotope effect and radical inhibition studies.
Mn(ii)/O2-promoted oxidative annulation of vinyl isocyanides with boronic acids: Synthesis of multi-substituted isoquinolines
Wang, Hao,Yu, Yang,Hong, Xiaohu,Xu, Bin
supporting information, p. 13485 - 13488 (2015/01/16)
An efficient manganese(ii)/O2-promoted oxidative radical cascade reaction was developed for the modular synthesis of multi-substituted isoquinolines from easily accessible vinyl isocyanides and boronic acids.
