25371-96-4 Usage
Description
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE, also known as TRIM, is a potent inhibitor of neuronal and inducible nitric oxide synthases, with IC50 values of 28.2 and 27.0 μM, respectively. It also inhibits endothelial NOS, albeit with lower potency (IC50 = 1057.5 μM). TRIM exhibits antinociceptive activity in vivo, making it a promising candidate for various applications.
Uses
Used in Pharmaceutical Industry:
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE is used as a therapeutic agent for the inhibition of neuronal nitric oxide synthase, which plays a crucial role in various physiological and pathological processes. Its ability to inhibit this enzyme makes it a potential candidate for the treatment of neurological disorders and pain management.
Used in Research Applications:
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE is used as a research tool for studying the role of nitric oxide synthases in various biological processes. Its potent inhibitory activity allows researchers to investigate the effects of nitric oxide synthase inhibition on cellular functions and signaling pathways.
Used in Drug Development:
1-(2-TRIFLUOROMETHYLPHENYL)IMIDAZOLE is used as a lead compound in the development of new drugs targeting nitric oxide synthases. Its antinociceptive activity and inhibitory properties make it a valuable starting point for the design and synthesis of novel therapeutic agents for the treatment of pain and other related conditions.
Biological Activity
A potent inhibitor of neuronal and inducible NO synthases, with much lower affinity for the endothelial isoform (displays IC 50 values of 28.2, 27.0 and 1057.5 μ M respectively). Antinociceptive in vivo .
Biochem/physiol Actions
Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.
References
1) Handy?et al. (1995), The antinociceptive effect of 1-(2-trifluoromethylphenyl)imidazole (TRIM), a potent inhibitor of neuronal nitric oxide synthase in vitro, in the mouse; Br. J. Pharmacol.,?116?2349
2) Handy?et al. (1996),?Inhibition of nitric oxide synthase by 1-(2-trifluoromethylphenyl) imidazole (TRIM) in vitro: antinociceptive and cardiovascular effects; Br. J. Pharmacol.,?119?423
Check Digit Verification of cas no
The CAS Registry Mumber 25371-96-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,3,7 and 1 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 25371-96:
(7*2)+(6*5)+(5*3)+(4*7)+(3*1)+(2*9)+(1*6)=114
114 % 10 = 4
So 25371-96-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H7F3N2/c11-10(12,13)8-2-1-3-9(6-8)15-5-4-14-7-15/h1-7H
25371-96-4Relevant articles and documents
Cu-Al hydrotalcite: An efficient and reusable ligand-free catalyst for the coupling of aryl chlorides with aliphatic, aromatic, and N(H)-heterocyclic amines
Sreedhar,Arundhathi,Linga Reddy,Amarnath Reddy,Lakshmi Kantam
experimental part, p. 2517 - 2522 (2010/03/24)
Copper-aluminum hydrotalcite catalysts were effectively used in the coupling of aryl chlorides with aliphatic, aromatic, and N(H)-heterocyclic amines to afford the corresponding N-alkylated/arylated amines in excellent yields. The catalyst was quantitatively recovered from the reaction by simple filtration and reused for a number of cycles with almost consistent activity. Georg Thieme Verlag Stuttgart.
