25371-97-5

Basic information

• Product Name: 1-(3-TRIFLUOROMETHYLPHENYL)IMIDAZOLE
• Synonyms: 1-[3-(Trifluoromethyl)phenyl]-1H-imidazole;Imidazole, 1-(3-trifluoromethylphenyl)-;1-(3-TRIFLUOROMETHYLPHENYL)IMIDAZOLE;1-[3-(Trifluoromethyl)phenyl]-1H-imidazole 98%;1-[3-(Trifluoromethyl)phenyl]-1H-imidazole98%;1-(3-TRIFLUOROMETHYLPHENYL)IMIDAZOLE 98%;3-(1H-Imidazol-1-yl)benzotrifluoride
• CAS NO: 25371-97-5
• Molecular Formula: C10H7F3N2
• Molecular Weight: 212.17
• Product Categories: Imidazol&Benzimidazole
• Mol File: 25371-97-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 70 °C
• Flash Point: 124.8 °C
• Appearance: /
• Density: 1,32 g/cm3
• Vapor Pressure: 0.00918mmHg at 25°C
• Refractive Index: 1.522
• PKA: 5.22±0.10(Predicted)
• CAS DataBase Reference: 1-(3-TRIFLUOROMETHYLPHENYL)IMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-TRIFLUOROMETHYLPHENYL)IMIDAZOLE(25371-97-5)
• EPA Substance Registry System: 1-(3-TRIFLUOROMETHYLPHENYL)IMIDAZOLE(25371-97-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 25371-97-5(Hazardous Substances Data)

Usage

General Description

1-(3-Trifluoromethylphenyl)imidazole is a chemical compound with the molecular formula C10H7F3N2. It is a white to off-white crystalline powder that is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. 1-(3-TRIFLUOROMETHYLPHENYL)IMIDAZOLE is a member of the imidazole family, which are heterocyclic organic compounds containing a five-membered ring with two non-adjacent nitrogen atoms. The trifluoromethyl group on the phenyl ring provides unique properties to this compound, making it valuable in a variety of chemical reactions and applications. Additionally, this compound has potential applications in the development of new materials and in medicinal chemistry due to its structural features and electronic properties.

InChI:InChI=1/C10H7F3N2/c11-10(12,13)8-1-3-9(4-2-8)15-6-5-14-7-15/h1-7H

Upstream product

• 288-32-4 1H-imidazole 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 

Relevant articles and documents

Steric effects on acetate-assisted cyclometallation ofmeta-substitutedN-phenyl andN-benzyl imidazolium salts at [MCl2Cp*]2(M = Ir, Rh)

meta-SubstitutedN-phenyl,N′-methyl andN-benzyl,N′-methyl imidazolium salts undergo acetate-assisted cyclometallation to provide mixtures oforthoandparasubstituted cyclometallated complexes. The effect of the substituents on the isomer ratios is discussed; steric effects are more important in the 6-membered rings derived from theN-benzyl imidazolium salts than 5-membered rings from theN-phenyl salts. Comparisons are made to steric effects with some other common directing groups.

Efficient and reusable catalytic system of Cul-PEG for n-arylation of imidazoles

A simple, efficient, and recyclable catalytic system of CuI-poly(ethylene glycol) (PEG) was developed for the N-arylation of imidazoles with aryl halides to afford corresponding N-arylimidazoles in good to excellent yields under mild conditions and free of any additional ligands and solvents. The isolation of the products was readily performed by simple extraction with ether, and the catalytic system could be reused without remarkable loss of activity even after six runs.

Ninhydrin: an efficient ligand for the Cu-catalyzed N-arylation of nitrogen-containing heterocycles with aryl halides

Cu2O/ninhydrin was found to be an efficient catalyst system for the N-arylation of nitrogen-containing heterocycles with aryl and heteroaryl iodides, bromides and even unactivated chlorides to give the products in moderate to excellent yields.