25373-49-3 Usage
Description
2-(1H-IMIDAZOL-1-YL)BENZENECARBONITRILE, also known as 2-(1H-Imidazol-1-yl)benzonitrile, is a chemical compound characterized by its grey powder form. It is known for its potent inhibitory effects on microsomal drug metabolism, which makes it a significant substance in the field of pharmaceuticals and drug development.
Uses
Used in Pharmaceutical Industry:
2-(1H-IMIDAZOL-1-YL)BENZENECARBONITRILE is used as a metabolic inhibitor for enhancing the efficacy and safety of various drugs. Its ability to inhibit microsomal drug metabolism allows for better control over drug interactions and side effects, leading to improved therapeutic outcomes.
Used in Drug Development:
In the realm of drug development, 2-(1H-IMIDAZOL-1-YL)BENZENECARBONITRILE serves as a valuable tool for studying and understanding the metabolic pathways of new drug candidates. By inhibiting specific metabolic enzymes, researchers can gain insights into the drug's metabolism, distribution, and potential toxicity, thereby facilitating the optimization of drug formulations and dosing regimens.
Used in Toxicology Research:
2-(1H-IMIDAZOL-1-YL)BENZENECARBONITRILE is also utilized in toxicology research to investigate the role of microsomal enzymes in the metabolism of toxic substances. This can help in the identification of potential drug-drug or drug-toxicant interactions, as well as in the development of strategies to mitigate adverse effects caused by these interactions.
Overall, 2-(1H-IMIDAZOL-1-YL)BENZENECARBONITRILE plays a crucial role in various applications across the pharmaceutical and related industries, primarily due to its potent inhibitory effects on microsomal drug metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 25373-49-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,3,7 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 25373-49:
(7*2)+(6*5)+(5*3)+(4*7)+(3*3)+(2*4)+(1*9)=113
113 % 10 = 3
So 25373-49-3 is a valid CAS Registry Number.
InChI:InChI=1/C10H7N3/c11-7-9-3-1-2-4-10(9)13-6-5-12-8-13/h1-6,8H
25373-49-3Relevant articles and documents
Design of an Electron-Withdrawing Benzonitrile Ligand for Ni-Catalyzed Cross-Coupling Involving Tertiary Nucleophiles
Edjoc, Racquel K.,Mills, L. Reginald,Rousseaux, Sophie A. L.
supporting information, p. 10422 - 10428 (2021/07/26)
The design of new ligands for cross-coupling is essential for developing new catalytic reactions that access valuable products such as pharmaceuticals. In this report, we exploit the reactivity of nitrile-containing additives in Ni catalysis to design a benzonitrile-containing ligand for cross-coupling involving tertiary nucleophiles. Kinetic and Hammett studies are used to elucidate the role of the optimized ligand, which demonstrate that the benzonitrile moiety acts as an electron-acceptor to promote reductive elimination over β-hydride elimination and stabilize low-valent Ni. With these conditions, a protocol for decyanation-metalation and Ni-catalyzed arylation is conducted, enabling access to quaternary α-arylnitriles from disubstituted malononitriles.
Magnetically retrievable lepidocrocite supported copper oxide nanocatalyst (Fe-CuO) for N-arylation of imidazole
Sivakami,Babu, S. Ganesh,Dhanuskodi,Karvembu
, p. 8571 - 8578 (2015/03/03)
A simple and efficient lepidocrocite-supported copper oxide catalyst (Fe-CuO) has been successfully prepared by a simple precipitation method in aqueous medium from readily available inexpensive starting materials and was used as a heterogeneous nanocatal
Mild transition-metal-free amination of fluoroarenes catalyzed by fluoride ions
Dehe, Daniel,Munstein, Isabel,Reis, Andreas,Thiel, Werner R.
experimental part, p. 1151 - 1154 (2011/05/02)
Trimethylsilyl-protected heterocycles undergo N-C bond formation with a variety of electron-deficient fluoroarenes catalyzed by fluoride ions. This reaction avoids stoichiometric amounts of base and thus makes N-arylheterocycles accessible in a very mild and transition-metal-free way.
