25373-56-2

Basic information

• Product Name: (2-IMIDAZOL-1-YL-PHENYL)METHANOL
• Synonyms: (2-IMIDAZOL-1-YL-PHENYL)METHANOL;(2-IMIDAZOL-1-YL-PHENYL)METHANOL 95%;Zinc02563837
• CAS NO: 25373-56-2
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.2
• Mol File: 25373-56-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 102-104 °C
• Boiling Point: 380.2 °C at 760 mmHg
• Flash Point: 183.7 °C
• Appearance: /
• Density: 1.16 g/cm³
• Vapor Pressure: 1.85E-06mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.18±0.10(Predicted)
• CAS DataBase Reference: (2-IMIDAZOL-1-YL-PHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2-IMIDAZOL-1-YL-PHENYL)METHANOL(25373-56-2)
• EPA Substance Registry System: (2-IMIDAZOL-1-YL-PHENYL)METHANOL(25373-56-2)

Safety Data

• Hazardous Substances Data: 25373-56-2(Hazardous Substances Data)

Usage

General Description

"(2-Imidazol-1-yl-phenyl)methanol" is a chemical compound that belongs to the class of organic compounds known as benzyl alcohols. These are aromatic compounds containing a benzene ring substituted by a hydroxymethyl group (-CH2OH), the phenyl group is connected to imidazole at the first position making this chemical unique. Imidazole in this molecule contributes to the complexity, solubility, and reactivity of its structure. Imidazoles are prevalent in many biologically active compounds like enzymes and antifungal drugs. This molecule, with its aromaticity and hydroxymethyl group, can participate in chemical reactions and potentially has numerous applications in research, medical, pharmaceutical, and industrial fields. The exact properties and uses of such particular imidazole derivatives with phenylmethanol are subject to studies and research.

InChI:InChI=1/C10H10N2O/c13-7-9-3-1-2-4-10(9)12-6-5-11-8-12/h1-6,8,13H,7H2

Upstream product

• 246046-82-2 2-Imidazol-1-yl-benzoic acid methyl ester 
• 288-32-4 1H-imidazole 
• 5159-41-1 2-iodobenzyl alcohol 
• 394-35-4 methyl 2-fluorobenzoate 

Downstream Products

• 117296-93-2 1-(2-Chloromethyl-phenyl)-1H-imidazole 
• 117323-65-6 2-[2-(2-Imidazol-1-yl-benzylsulfanyl)-imidazol-1-yl]-pyridine 

Relevant articles and documents

Copper-catalyzed N-arylation of imidazoles and benzimidazoles

(Chemical Equation Presented) 4,7-Dimethoxy-1,10-phenanthroline (L1c) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazoles and benzimidazoles with both aryl iodides and bromides under mild conditions. Further optimization of the system has revealed that the addition of poly(ethylene glycol) accelerates this reaction. A variety of hindered and functionalized imidazoles, benzimidazoles, and aryl halides were transformed in good to excellent yields. Heteroaryl halides were also coupled in moderate to good yields. We also present the results obtained from a series of coupling reactions, which directly compare the use of L1c with other recently reported ligands.

2-[(2-Aminobenzyl)sulfinyl]-1-(2-pyridyl)-1,4,5,6- tetrahydrocyclopent[d]imidazoles as a novel class of gastric H+/K+-ATPase inhibitors

Substituted 2-sulfinylimidazoles were synthesized and investigated as potential inhibitors of gastric H+/K+-ATPase. The 4,5-unsubstituted imidazole series 6-11 and the 1,4,5,6-tetrahydrocyclopent[d]imidazole series 12 were found to be potent inhibitors of the acid secretory enzyme H+/K+- ATPase. Structure-activity relationships indicate that the substitution of 2- pyridyl groups at the 1-position of the imidazole moiety combined with (2- aminobenzyl)sulfinyl groups at the 2-position leads to highly active compounds with a favorable chemical stability. Other substitution patterns in the imidazole moiety result in reducing biological activities. 2-[(2- Aminobenzyl)sulfinyl]-1-[2-(3-methylpyridyl)]-1,4,5,6- tetrahydrocyclopent[d]imidazole (12h, T-776) was selected for further development as a potential clinical candidate. Extensive study on the acid degradation of 12h indicates a mechanism of action different from that of omeprazole, the first H+/K+-ATPase inhibitor introduced to the market.