25412-53-7

Basic information

• Product Name: 4-ACETAMIDOBENZYLAMINE
• Synonyms: N-[4-(AMINOMETHYL)PHENYL]ACETAMIDE;4-ACETAMIDOBENZYLAMINE;p-(Aminomethyl)acetanilide
• CAS NO: 25412-53-7
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.2
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 25412-53-7.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 374.8°Cat760mmHg
• Flash Point: 180.5°C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.603
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 4-ACETAMIDOBENZYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ACETAMIDOBENZYLAMINE(25412-53-7)
• EPA Substance Registry System: 4-ACETAMIDOBENZYLAMINE(25412-53-7)

Safety Data

• Hazardous Substances Data: 25412-53-7(Hazardous Substances Data)

Usage

General Description

4-ACETAMIDOBENZYLAMINE is a chemical compound with the molecular formula C9H12N2O. It is an aromatic amine derivative, containing both an amide and an amine functional group in its structure. 4-ACETAMIDOBENZYLAMINE is commonly used in organic synthesis as a precursor for the preparation of various pharmaceuticals, as well as in the production of dyes and fine chemicals. It is also utilized as a building block in the synthesis of heterocyclic compounds and as a reagent in chemical research. Additionally, 4-ACETAMIDOBENZYLAMINE has potential applications in the fields of medicinal chemistry and drug discovery, making it a valuable and versatile compound in the chemical industry.

InChI:InChI=1/C9H12N2O/c1-7(12)11-9-4-2-8(6-10)3-5-9/h2-5H,6,10H2,1H3,(H,11,12)

Upstream product

• 4403-71-8 (4-aminomethyl)aniline 
• 108-24-7 acetic anhydride 
• 35704-19-9 N-(4-cyanophenyl)acetamide 
• 1253778-94-7 N-(4-((N-(phenylsulfonyl)phenylsulfonamido)methyl)phenyl)acetamide 
• 122-85-0 para-acetamidobenzaldehyde 

Downstream Products

• 122-85-0 para-acetamidobenzaldehyde 
• 91941-10-5 N-{4-[(6-Amino-5-nitro-pyridin-2-ylamino)-methyl]-phenyl}-acetamide 
• 1027158-05-9 N-{4-[(7-chloro-6-nitro-quinazolin-4-ylamino)-methyl]-phenyl}-acetamide 
• 389601-56-3 N-(4-acetylamino-phenylmethyl)-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide 
• 1061862-41-6 N-[4-(acetylamino)benzyl]-4-[(trifluoromethyl)thio]benzamide 
• 1581755-38-5 (R)-N-(4-acetamidobenzyl)-1-(1-(naphthalen-1-yl)ethyl)-piperidine-4-carboxamide 

Relevant articles and documents

Ambient-Temperature Synthesis of Primary Amines via Reductive Amination of Carbonyl Compounds

Efficient synthesis of primary amines via low-temperature reductive amination of carbonyl compounds using NH3 and H2 as the nitrogen and hydrogen resources is highly desired and challenging in the chemistry community. Herein, we employed naturally occurring phytic acid as a renewable precursor to fabricate titanium phosphate (TiP)-supported Ru nanocatalysts with different reduction degrees of RuO2 (Ru/TiP-x, x represents the reduction temperature) by combining ball milling and molten-salt processes. Very interestingly, the obtained Ru/TiP-100 had good catalytic performance for the reductive amination of carbonyl compounds at ambient temperature, resulting from the synergistic cooperation of the support (TiP) and the Ru/RuO2 with a suitable proportion of Ru0 (52%). Various carbonyl compounds could be efficiently converted into the corresponding primary amines with high yields. More importantly, the conversion of other substrates with reducible groups could also be achieved at ambient temperature. Detailed investigations indicated that the partially reduced Ru and the support (TiP) were indispensable. The high activity and selectivity of Ru/TiP-100 catalyst originates from the relatively high acidity and the suitable electron density of metallic Ru0.

Liquid-phase hydrogenation of nitriles to amines facilitated by a co(ii)/zn(0) pair: a ligand-free catalytic protocol

The given report introduces a simple and user-friendly in situ method for the production of catalytically active cobalt particles. The approach circumvents the use of air-and moisture-sensitive reductants as well as the application of anhydrous Co-precursor salts. Accordingly, the described catalytic system is readily assembled under open-flask conditions by simply combining the components in the reaction vessel. Therefore, the arduous charging procedure of the reaction autoclave in a glovebox under an inert gas atmosphere is no longer necessary. In fact, the catalytically active material is obtained upon treatment of readily available Co(OAc)2·4 H2O with benign commercial Zn powder. The catalytic performance of the resultant material was tested in the heterogeneous hydrogenation of nitriles to the corresponding primary amines. Both activity and selectivity of the cobalt catalyst are significantly enhanced if a triflate-based Lewis acid and ammonia is added to the reaction mixture.

Selective Hydrogenation of Nitriles to Primary Amines by using a Cobalt Phosphine Catalyst

A general procedure for the catalytic hydrogenation of nitriles to primary amines by using a non-noble metal-based system is presented. Co(acac)3 in combination with tris[2-(dicyclohexylphosphino)ethyl]phosphine efficiently catalyzes the selective hydrogenation of a wide range of (hetero)aromatic and aliphatic nitriles to give the corresponding amines.