25412-66-2

Basic information

• Product Name: 3-METHOXY-BENZAMIDINE
• Synonyms: 3-MethoxybenziMidaMide
• CAS NO: 25412-66-2
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Mol File: 25412-66-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 265.3°C at 760 mmHg
• Flash Point: 114.2°C
• Appearance: /
• Density: 1.13g/cm³
• Vapor Pressure: 0.00925mmHg at 25°C
• Refractive Index: 1.548
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 11?+-.0.50(Predicted)
• CAS DataBase Reference: 3-METHOXY-BENZAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-BENZAMIDINE(25412-66-2)
• EPA Substance Registry System: 3-METHOXY-BENZAMIDINE(25412-66-2)

Safety Data

• Hazardous Substances Data: 25412-66-2(Hazardous Substances Data)

Usage

General Description

3-Methoxy-benzamidine is a chemical compound consisting of a benzene ring with a methoxy group and an amidine functional group. It is commonly used as a reagent in organic synthesis and serves as a precursor in the production of certain pharmaceuticals and other fine chemicals. 3-Methoxy-benzamidine has been found to inhibit the activity of various proteases and is used as a tool in biochemical research to study the role of these enzymes in biological processes. It is also used in the development of new drug candidates targeting protease activity and in the study of protease-related diseases. Additionally, 3-Methoxy-benzamidine has potential applications in the field of medical diagnostics as a substrate for the detection of protease activity in biological samples.

InChI:InChI=1/C8H10N2O/c1-11-7-4-2-3-6(5-7)8(9)10/h2-5H,1H3,(H3,9,10)

Upstream product

• 1527-89-5 3-methoxybenzonitrile 
• 73647-50-4 N'-hydroxy-3-methoxybenzenecarboximidamide 

Downstream Products

• 1001755-35-6 [2-(3-Methoxy-phenyl)-3H-imidazol-4-yl]-methanol 
• 582306-99-8 4-amino-6-(2,4-dichloro-phenyl)-2-(3-methoxy-phenyl)-pyrimidine-5-carbonitrile 
• 1026594-08-0 5-Chloromethyl-2-(3-methoxy-phenyl)-1H-imidazole 
• 1416892-54-0 C₁₆H₁₃N₃O₃ 
• 1416892-55-1 C₂₃H₂₆N₄O₄ 
• 1898-74-4 2,4-diphenyl-1,3,5-triazine 
• 1613637-87-8 2-(3-methoxyphenyl)-4-phenyl-1,3,5-triazine 
• 1613637-80-1 2,4-bis(3-methoxyphenyl)-1,3,5-triazine 

Relevant articles and documents

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation

Based on the novel allosteric site of deoxyhypusine synthase (DHPS), two series of 30 novel 5-(2-methoxyphenoxy)-2-phenylpyrimidin-4-amine derivatives as DHPS inhibitors were designed and synthesized. Among them, compound8m, with the best DHPS inhibitory potency (IC50= 0.014 μM), exhibited excellent inhibition against melanoma cells, which was superior to that of GC7. Besides, molecular docking and molecular dynamics (MD) simulations further proved that compound8mwas tightly bound to the allosteric site of DHPS. Flow cytometric analysis and enzyme-linked immunosorbent assay (ELISA) showed that compound8mcould inhibit the intracellular reactive oxygen species (ROS) level. Furthermore, by western blot analysis, compound8meffectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. Moreover, both Transwell analysis and wound healing analysis showed that compound8mcould inhibit the invasion and migration of melanoma cells. In thein vivostudy, the tumor xenograft model showed that compound8meffectively inhibited melanoma development with low toxicity.

SUBSTITUTED TRIAZOLES AND THEIR USE FOR TREATMENT AND/OR PREVENTION NEUROLOGICAL AND PSYCHIATRIC DISORDERS

This invention relates to compounds of formula (I), their use as positive allosteric modulators of mGlu5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. A, B, Ar, R1, R2, R3 have meanings given in the description.

Direct Conversion of Amidoximes to Amidines via Transfer Hydrogenation

Amidoximes, O-alkylamidoximes, and O-acylamidoximes are directly converted to amidines by reaction with ammonium formate and Pd/C in acetic acid.