25445-77-6 Usage
Description
4-PHENYL-1,2,3-THIADIAZOLE is a chemical compound belonging to the 1,2,3-thiadiazole family, characterized by an off-white to light brown solid appearance. It is known for its selective inhibitory activity against specific cytochrome P450 (CYP450) enzymes, such as CYP2B4 and CYP2E1, at a concentration of 100 μM. 4-PHENYL-1,2,3-THIADIAZOLE, along with its derivatives, is widely utilized in various applications across different industries, including pharmaceuticals, agriculture, and as a chemical intermediate.
Uses
Used in Pharmaceutical Industry:
4-PHENYL-1,2,3-THIADIAZOLE is used as a selective inhibitor for certain CYP450 enzymes, specifically CYP2B4 and CYP2E1, for the purpose of studying their role in drug metabolism and potential drug-drug interactions. This selective inhibition helps researchers understand the metabolic pathways and optimize drug formulations to minimize adverse effects and improve therapeutic outcomes.
Used in Agricultural Industry:
In the agricultural sector, 4-PHENYL-1,2,3-THIADIAZOLE and its derivatives are used as fungicides, herbicides, and plant growth regulators. They help protect crops from various diseases and pests, ensuring higher yields and better crop quality.
Used as a Chemical Intermediate:
4-PHENYL-1,2,3-THIADIAZOLE also serves as a valuable chemical intermediate in the synthesis of various organic compounds and pharmaceuticals. Its unique chemical structure allows for the development of new molecules with potential applications in different fields, such as medicine, materials science, and agrochemicals.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 28, p. 442, 1985 DOI: 10.1021/jm00382a009
Check Digit Verification of cas no
The CAS Registry Mumber 25445-77-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,4,4 and 5 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 25445-77:
(7*2)+(6*5)+(5*4)+(4*4)+(3*5)+(2*7)+(1*7)=116
116 % 10 = 6
So 25445-77-6 is a valid CAS Registry Number.
InChI:InChI=1/C8H6N2S/c1-2-4-7(5-3-1)8-6-11-10-9-8/h1-6H
25445-77-6Relevant articles and documents
Diiiodine/Potassium Persulfate Mediated Synthesis of 1,2,3-Thiadiazoles from N -Tosylhydrazones and a Thiocyanate Salt as a Sulfur Source under Transition-Metal-Free Conditions
Lu, Yuhan,Sun, Yadong,Abdukader, Ablimit,Liu, Chenjiang
supporting information, p. 1044 - 1048 (2021/05/05)
A highly efficient method for the synthesis of 1,2,3-thiadiazoles has been developed by utilizing readily available tosylhydrazones and ammonium thiocyanate with ecofriendly EtOH as the solvent at room temperature. The reaction shows a wide scope of subst
Selective transformations of 2-(p-toluenesulfonyl)-N-tosylhydrazones to substituted 1,2,3-thiadiazoles
Feng, Yijiao,He, Jing,Li, Weiwei,Yang, Zhen,Wei, Yueting,Liu, Ping,Zhao, Jixing,Gu, Chengzhi,Wang, Wenli
supporting information, (2020/12/09)
Selective transformations of 2-(p-toluenesulfonyl)-N-tosylhydrazones with different sulfur sources have been established. A series of 4-aryl-1,2,3-thiadiazoles and novel 4-aryl-5-tosyl-1,2,3-thiadiazoles were selectively constructed by the adjustment of reaction conditions. These protocols feature short reaction time, good compatibility of functional group, easily available materials, and good selectivity.
Preparation method of thiadiazole containing aryl group and alkyl group
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Paragraph 0020-0024, (2019/08/30)
The invention discloses a preparation method of thiadiazole containing an aryl group and an alkyl group. Methyl ketone, p-toluenesulfonhydrazide and potassium thiocyanate which are used as a substrateundergo a three-component one-pot reaction in DMSO used
